Number of patients Number of person-years Number of patients with each comorbidity Incident rate (per 100,000 person-years) Crude HR (95%CI) Multivariate-adjusted HR* (95% CI)
Cardiovascular comorbidities Cardiovascular comorbidities Cardiovascular comorbidities Cardiovascular comorbidities Cardiovascular comorbidities Cardiovascular comorbidities Cardiovascular comorbidities
Gender
Female
9874
67453.32
3044
4512.75
1.00
1.00
Male
5223
35926.71
1766
4915.56
1.09 (1.03~1.16)
1.10 (1.04~1.17)
Age
≤ 16
356
3055.91
5
163.62
1.00
1.00
>16
14741
100324.12
4805
4789.48
28.63 (11.91~68.01)
29.11 (12.11~69.98)
Biologic agents
No
14976
102282.55
4801
4693.86
1.00
1.00
Yes
121
1097.49
9
820.05
0.18 (0.09~0.35)
0.18 (0.09~0.35)
Metabolic comorbidities Metabolic comorbidities Metabolic comorbidities Metabolic comorbidities Metabolic comorbidities Metabolic comorbidities Metabolic comorbidities
Gender
Female
8405
53287.36
3663
43581.20
1.00
1.00
Male
4979
33172.56
2017
40510.14
0.89 (0.85~0.94)
0.90 (0.85~0.95)
Age
≤ 16
350
2906.98
28
8000.00
1.00
1.00
>16
13034
83552.95
5652
43363.51
6.79 (4.69~9.84)
6.72 (4.64~9.75)
Biologic agents
No
13295
85638.11
5671
42655.13
1.00
1.00
Yes
89
821.82
9
10112.36
0.17 (0.09~0.33)
0.17 (0.09~0.32)
Rheumatology comorbidities Rheumatology comorbidities Rheumatology comorbidities Rheumatology comorbidities Rheumatology comorbidities Rheumatology comorbidities Rheumatology comorbidities
Gender
Female
11742
91810.66
1472
12536.19
1.00
1.00
Male
6372
51469.19
797
12507.85
0.97 (0.89~1.06)
0.97 (0.89~1.06)
Age
≤ 16
339
2838.61
20
5899.71
1.00
1.00
>16
17775
140441.23
2249
12652.60
2.25 (1.45~3.50)
2.25 (1.45~3.49)
Biologic agents
No
17976
142017.51
2262
12583.44
1.00
1.00
Yes
138
1262.33
7
5072.46
0.36 (0.17~0.75)
0.35 (0.17~0.74)
Oncology comorbidities Oncology comorbidities Oncology comorbidities Oncology comorbidities Oncology comorbidities Oncology comorbidities Oncology comorbidities
Gender
Female
1974
106819.39
12720
644376.90
1.00
1.00
Male
1174
60389.63
6961
592930.15
1.04 (0.97~1.12)
1.04 (0.97~1.12)
Age
≤ 16
10
3121.68
358
3580000.00
1.00
1.00
>16
3138
164087.34
19323
615774.38
6.23 (3.35~11.58)
6.26 (3.37~11.64)
Biologic agents
No
3125
165753.94
19525
624800.00
1.00
1.00
Yes
23
1455.08
156
678260.87
0.65 (0.43~0.98)
0.65 (0.43~0.98)
Infection comorbidities Infection comorbidities Infection comorbidities Infection comorbidities Infection comorbidities Infection comorbidities Infection comorbidities
Gender
Female
12278
100003.67
646
5261.44
1.00
1.00
Male
6666
55516.31
446
6690.67
1.25 (1.11~1.41)
1.26 (1.11~1.42)
Age
≤ 16
357
3095.73
5
1400.56
1.00
1.00
>16
18587
152424.25
1087
5848.17
4.37 (1.81~10.51)
4.50 (1.87~10.83)
Biologic agents
No
18797
154185.62
1085
5772.20
1.00
1.00
Yes
147
1334.37
7
4761.90
0.77 (0.36~1.61)
0.81 (0.38~1.70)
Miscellaneous comorbidities Miscellaneous comorbidities Miscellaneous comorbidities Miscellaneous comorbidities Miscellaneous comorbidities Miscellaneous comorbidities Miscellaneous comorbidities
Gender
Female
8545
53604.52
3206
5980.84
1.00
1.00
Male
4502
28281.48
1790
6329.23
1.06 (1.01~1.13)
1.07 (1.01~1.13)
Age
≤ 16
273
2094.36
49
2339.62
1.00
1.00
>16
12774
79791.65
4947
6199.90
2.52 (1.90~3.34)
2.55 (1.92~3.38)
Biologic agents
No
8601
53954.71
3220
5967.97
1.00
1.00
Yes
93
826.53
7
846.92
0.15 (0.07~0.31)
0.15 (0.07~0.31)