2.3. Risk of bias – study quality assessment
Risk of bias in individual studies was assessed independently by two investigators. Discrepancies were resolved through discussion between three investigators. RCTs were assessed using the revised Cochrane collaboration Risk of Bias tool 2 for randomized controlled trials (RoB2) 15, and NRSI were assessed using Cochrane collaboration Risk of bias in non-randomized studies of interventions (ROBINS-I) tool (see Supplement for details) 16.