Genotype and allele frequencies
Genotype distributions were in Hardy–Weinberg equilibrium, indicating that the subjects were representative of the general population. The frequencies of the genotypes and alleles of IL2RA , IL-10 ,IFN-γ, IRF5 , and CCR2 between EBV-HLH and control groups are shown in Table 2.
The IL2RA rs2104286 AA genotype and A allele were significantly more frequent in the EBV-HLH group than in the control group, suggesting that they might be associated with a significantly increased risk of EBV-HLH (OR = 2.894, 95% CI = 1.374–6.094 and OR = 2.077, 95% CI = 1.232–3.502, respectively). However, the frequencies of theIL2RA rs12722489 and rs11594656 genotypes and alleles were similar in the EBV-HLH and control groups (P > 0.05).
The IL-10 rs1800896 AA genotype and A allele were more frequent in the EBV-HLH group, suggesting that they might be associated with a significantly increased risk of EBV-HLH (OR = 3.792, 95% CI = 1.779–8.080 and OR = 2.194, 95% CI = 1.279–3.763, respectively). The frequencies of IL-10 rs1800872 AC and CC genotypes and C allele were significantly higher in the EBV-HLH group, and the CC genotype and C allele were also associated with a significantly increased risk of EBV-HLH (OR = 6.222, 95% CI = 1.330–29.109 and OR = 2.176, 95% CI = 1.257–3.767,respectively). Meanwhile, the distribution of IL-10rs1800871 was similar in both groups (P > 0.05).
In addition, there were no significant differences in the frequencies ofIFN-γ rs2430561 and IRF5 rs2004640 genotypes and alleles between the two groups (P > 0.05) (Table 2).