Table 2. Genotype and allele frequencies in children with Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis and controls Table 2. Genotype and allele frequencies in children with Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis and controls Table 2. Genotype and allele frequencies in children with Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis and controls Table 2. Genotype and allele frequencies in children with Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis and controls Table 2. Genotype and allele frequencies in children with Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis and controls Table 2. Genotype and allele frequencies in children with Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis and controls Table 2. Genotype and allele frequencies in children with Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis and controls
Gene SNPs Patients (freq) Controls (freq) χ2 P value
IL2RA rs2104286 Genotype
AA 36(54.55%) 17(29.31%) 8.056 0.018*
AG 21(31.82%) 28(48.28%)
GG 9(13.64%) 13(22.41%)
allele
A 93(70.45%) 62(53.45%) 7.619 0.006*
G 39(29.55%) 54(46.55%)
rs12722489 Genotype
GG 49(74.24%) 42(72.41%) 0.060 0.971
AG 14(21.21%) 13(22.41%)
AA 3(4.55%) 3(5.18%)
allele
G 112(84.85%) 97(83.62%) 0.070 0.791
A 20(15.15%) 19(16.38%)
rs11594656 Genotype
TT 60(90.91%) 53(91.38%) 0.008 0.927
AT 6(9.09%) 5(8.62%)
allele
T 126(95.45%) 111(95.69%) 0.008 0.928
A 6(4.55%) 5(4.31%)
IL-10 rs1800896 Genotype
AA 39(59.09%) 16(27.59%) 12.732 0.002*
AG 21(31.82%) 35(60.34%)
GG 6(9.09%) 7(12.07%)
allele
A 99(75.00%) 67(61.21%) 8.293 0.004*
G 33(25.00%) 49(38.79%)
rs1800871 Genotype
TT 18(27.27%) 20(34.48%) 1.169 0.557
TC 35(53.03%) 30(51.72%)
CC 13(19.70%) 8(13.79%)
allele
T 71(53.79%) 70(60.34%) 1.082 0.298
C 61(46.21%) 46(39.66%)
rs1800872 Genotype
AA 24(36.36%) 32(55.17%) 8.472 0.014*
AC 30(45.45%) 24(41.38%)
CC 12(18.18%) 2(3.45%)
allele
A 78(59.09%) 88(75.86%) 7.847 0.005*
C 54(40.91%) 28(24.14%)
IFN-γ rs2430561 Genotype
TT 50(75.76%) 36(62.07%) 4.665 0.097
AT 13(19.70%) 21(36.21%)
AA 3(4.55%) 1(1.72%)
allele
T 113(85.61%) 93(80.17%) 1.296 0.255
A 19(14.39%) 23(19.83%)
IRF5 rs2004640 Genotype
TT 16(24.24%) 7(12.07%) 4.058 0.131
TG 37(56.06%) 33(56.90%)
GG 13(19.70%) 18(31.03%)
allele
T 69(52.27%) 47(40.52%) 3.427 0.064
G 63(47.73%) 69(59.48%)
CCR2 rs1799864 Genotype
GG 39(59.09%) 38(65.52%) 2.390 0.303
AG 20(30.30%) 18(31.03%)
AA 7(10.61%) 2(3.45%)
allele
G 98(74.24%) 94(81.03%) 1.629 0.202
A 34(25.76%) 22(18.97%)
SNP: single nucleotide polymorphism values calculated from two-sided χ2 tests. SNP: single nucleotide polymorphism values calculated from two-sided χ2 tests. SNP: single nucleotide polymorphism values calculated from two-sided χ2 tests. SNP: single nucleotide polymorphism values calculated from two-sided χ2 tests. SNP: single nucleotide polymorphism values calculated from two-sided χ2 tests. SNP: single nucleotide polymorphism values calculated from two-sided χ2 tests. SNP: single nucleotide polymorphism values calculated from two-sided χ2 tests.