No Previous Conduction Defect No Previous Conduction Defect No Previous Conduction Defect Previous Conduction Defect Previous Conduction Defect Previous Conduction Defect
no PPI (n=114) PPI (n=17) P value no PPI (n= 32) PPI (n=16) P value
Clinical characteristics
Age 79.54±7.45 83.58±3.65 0.030 80.59±6.53 80.12±5.41 0.806
Sex Male n (%) 42 (37) 4 (23) 0.287 11 (34) 9 (56) 0.154
CAD n (%) 41 (36) 5 (29) 0.584 8 (25) 3 (19) 0.636
NYHA III-IV n (%) 68 (60) 16 (94) 0.006 15 (47) 7 (44) 0.842
Previous stroke n (%) 1 (0.9) 1 (5,9) 0.120 1 (3) 0 (0) 0.485
Diabetes n (%) 35 (31) 4 (23) 0.536 14 (44) 7 (44) 1.000
Hypertension n (%) 95 (83) 16 (94) 0.247 30 (94) 15 (94) 1.000
PAD n (%) 19 (17) 3 (17) 0.933 8 (25) 2 (12) 0.325
COPD n (%) 26 (23) 3 (18) 0.636 9 (28) 5 (31) 0.827
CKD n (%) 24 (21) 5 (29) 0.584 15 (47) 5 (33) 0.392
Echo variables
EF (%) 53.09±8.91 54.47±5.94 0.541 53.35±4.78 55±34.47 0.260
Mean PG mmHg 48.21±13.40 53.12±17.77 0.193 46.40±10.82 48.81±16.94 0.559
CT variables
Eccentr index 16.73±6.53 21.27±3.40 0.021 16.27±6.25 15.57±5.83 0.794
Valve index 112.10±8.46 112.53±6.21 0.880 113.49±5.20 108.62±11.52 0.230
Cover index 14.47±15.64 11.82±5.32 0.581 10.91±7.81 12.49±5.53 0.613
FACT score 6.82±3.44 7.33±3.49 0.636 5.75±3.25 6.00±3.35 0.865
LVOT calcif n (%) 29 (26) 3 (17) 0.492 10 (33) 7 (44) 0.625
Asym cuspid calcif n (%) 80 (70) 11 (67) 0.835 26 (83) 12 (78) 0.763
RCC calcification (1-3) 1.27 1.67 0.217 1.08 1.67 0.223
LCC calcification (1-3) 1.27 1.50 0.491 0.83 1.11 0.448
NCC calcification (1-3) 1.53 2.50 0.004 1.92 1.89 0.956
Procedural variables
Self Expandable n (%) 98 (86) 17 (100) 0.101 20 (62) 13 (81) 0.194
Balloon Expandable n (%) 16 (14) 0 (0) 0.101 12 (38) 3 (19) 0.194
Size (#) 26.8±2.8 27.1±3.6 0.687 25.7±2.51 27.8±3.13 0.013
Balloon post dilat SE n (%) 33 (29) 3 (19) 0.393 7 (22) 1 (9) 0.343
Balloon post dilat BE n (%) 0 (0) 0 (0) - 4 (12) 0 (0) 0.544
Mean Impl Depth (mm) 7.43±3.54 8.38±3.21 0.323 8.15±2.92 9.57±2.72 0.186
Impl Depth NCC (mm) 6.97±3.94 8.17±3.61 0.262 7.97±3.15 9.04±3.27 0.375
Impl Depth LCC (mm) 7.90±3.53 8.59±3.62 0.476 8.32±3.00 10.11±2.41 0.094
Hematological variables
Hgb g/dl 12.2±1.7 12.1±1.5 0.919 12±1.6 12..6±1.6 0.209
CRP mg/l 4.7±6.6 5.6±8.5 0.663 4.7±6.2 3.4±4.2 0.598
Neutrophils admission 4.70±1.60 5.19±1.77 0.243 4.89±1.80 4.87±1.50 0.982
Lymphocytes admission 1.88±2.04 1.60±0.63 0.569 1.62±0.60 1.92±0.58 0.086
Neutrophils impl day 6.44±2.74 9.10±4.05 0.001 7.38±3.93 6.73±2.10 0.542
Lymphochytes impl day 1.53±2.02 1.04±0.40 0.329 1.25±0.52 1.35±0.47 0.527
Neutrophils discharge 4.75±1.79 5.51±1.68 0.101 5.50±2.40 5.37±1.93 0.850
Lymphocytes discharge 1.68±1.57 1.60±0.68 0.821 1.41±0.50 1.57±0.39 0.285
NLR admission 3.01±1.47 4.07±3.22 0.025 3.23±1.37 2.64±0.90 0.127
NLR impl day 5.84±3.78 10.81±7.81 0.000 6.62±4.26 5.48±2.32 0.236
NLR discharge 3.21±1.56 4.04±2.59 0.068 4.34±2.48 3.56±1.49 0.257