Extensive searching in the space of protein-ligand docking conformations was supported by the citizen volunteer computing project COVID-PHYM [17] implemented using the BOINC (Berkeley Open Infrastructure for Network Computing) platform [18]. Around 3.2 million poses were collected for each protein-ligand pair. Further details concerning the analysis of the docked positions are given as supplementary material, Section S2. For comparison with previous approaches, we also performed ensemble docking using the RdRp-CoV2 solved without RNA using the experimental structure deposited in the PDB entry 7BTF [19] (see supplementary material, Section S3).