We used the three-dimensional structures of the SARS-CoV-2 RNA-dependent RNA polymerase, solved with RNA nascent and template chains (RdRp-CoV2-RNA, Protein Database Bank entry 7BV1[15] ) and the 3 ligands evaluated (dATP, and the biologically active forms of the drugs remdesivir triphosphate [8,16] and tenofovir diphosphate[16]). Ligand structures, along with the type of atoms and the rotatable bonds considered in the docking calculations, are shown in the supplementary material, Section S1 (Figure S1).