Further, the TDF per-cell viral yield inhibition, ITDF can be computed as proportion 1-VirTDF /Virnull for each pair of case-control experiment where Virnull is the average number of virions produced per infectious viral particle without the presence of antiviral, and VerTDF the average number of new virions produced per infectious viral particle in the presence of TDF. The relation between ITDF and VR can be computed for m discrete time steps using the correspondence VirTDF /Virnull \(≃\)\(\sqrt[m]{VR}\) . Thus, we estimated the range of ITDF using the experimental VR values (n=12), and m ranging 5 to 1, which simplifies the model approximating a continuous length of the SARS-CoV-2 viral cycle ranging from 9.6 to 48 hours. Details on the derived calculation and experimental data can be found in Supplementary material Section S4.