Supplemental Figure 7 Silence of GPER cancels the effect of
estrogen on regulating peak I Na andI NaL. (A) Average I NaLdensity. n=10-25 cells, from 4-9 Petri dishes. (B) PeakI Na density. n=13-32 cells, from 4-11 Petri
dishes. (C-F) Values for k and V1/2 of (in)
activation. n=9-26 cells, from 4-11 Petri dishes. (G) τ value of
recovery from inactivation. n=5-17 cells, from 4-10 Petri dishes. (H)
Average I NaL density. n=9-26 cells, from 4-10
Petri dishes. (I) Peak I Na density. n=12-37
cells, from 4-11 Petri dishes. (J-M) Values for k and
V1/2 of (in) activation. n=8-34 cells, from 4-11 Petri
dishes. (N) τ value of recovery from inactivation. n=5-32 cells, from
5-11 Petri dishes. One-way ANOVA was used. Kruskal-Wallis test was used
selectively in the case of uneven variance. *P < 0.05,
**P < 0.01, ****P < 0.0001. GPER, G
protein coupled estrogen receptor. Insets: voltage clamp protocols.