5. Conclusion
In summary, the network pharmacology approach was performed to unveil the chemical basis and investigate the action mechanism of TwHF on CVD. 51 active compounds of TwHF and 5 core target genes of TwHF against CVD, including AKT1, APP, MAPK, PIK3CA and TP53 were identified. Based on the analysis of GO and KEGG, cancer pathway was found to be closely associated with the protective effect of TwHF on CVD. The present study provides a theoretical basis and a clue for the pharmacological mechanism study of TwHF on CVD. However, further experimental studies of these prediction results are needed to validate potential application.
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