Conclusion
Any patient with a malignancy who develops a neuromuscular syndrome
should be investigated for the possibility of paraneoplastic syndrome.
Patients with PV positive for JAK2 mutation can develop MG as a
paraneoplastic syndrome, in the absence of thymoma. PV shows good
response to hydroxyurea therapy and MG to steroid plus cholinergic
therapy. Interferon-alpha is an upcoming modality for cytoreductive
therapy in PV, which is also evidenced to bring about remission in MG.