3.5 Elevated BNP and Increased Mortality
The 835 severe/critical patients with BNP values recorded during
hospitalization were divided into BNP high (n=171) and BNP normal
(n=664) groups based on the upper reference limit (100 pg/mL). Survival
analysis was conducted on two groups using applying a mixed-effect Cox
model adjusted for age, sex, comorbidities, and hs-TNI, α-HBDH, CK-MB,
and LDH. As a result, the BNP normal group demonstrated a significantly
lower risk of mortality (Figure 6a ). The BNP level correctly
classified survivors and non-survivors with an area under the curve
(AUC) of 0.81 with the ideal threshold value based on the ROC curve of
62.17, a sensitivity of 71.7%, and a specificity of 80.6%
(Figure 6b ).
Pearson’s correlations were used to study the association between BNP
and other laboratory parameters. CRP (Figure 6c ), IL-6
(Figure 6d ), and D-dimer (Figure 6e ) showed a highly
positive correlation with BNP. By contrast, BNP level was significantly
negatively correlated with LYM% (Figure 6f ).