2.4 Transcriptional profiles
To characterize the expression patterns of SARS-CoV-2 receptors in the
heart, single-cell RNA sequencing (scRNA-seq) of 9,791 cells isolated
from 12 normal human hearts was performing. The scRNA-seq data were
obtained from the Gene Expression Omnibus (GEO) database with the
accession number GSE109816 (Wang et al., 2020b) and processed using theSeurat toolkit (Butler, Hoffman, Smibert, Papalexi & Satija,
2018). The expression profile of peripheral blood from 93 CAD patients
and 48 healthy individuals was analyzed using the Agilent-067406 Human
Microarray V4.0 platform (Aglient, Santa Clara, USA), and the data were
downloaded from the GEO database with the accession number GSE113079 (Li
et al., 2018).