Conclusions
To summarize, EBP50 suppressed FLS proliferation, migration and invasion, and induced apoptosis. These findings have therapeutic significance and indicate the potential of EBP50 as a therapeutic target for RA, because the EBP50-mediated effects on FLS involve targeting synovial hyperplasia. Further research is needed to investigate the pathways involved in these protective effects and clarify if EBP50 could reduce proinflammatory cytokine secretion from RA-FLS.