Conclusions
To summarize, EBP50 suppressed FLS proliferation, migration and
invasion, and induced apoptosis. These findings have therapeutic
significance and indicate the potential of EBP50 as a therapeutic target
for RA, because the EBP50-mediated effects on FLS involve targeting
synovial hyperplasia. Further research is needed to investigate the
pathways involved in these protective effects and clarify if EBP50 could
reduce proinflammatory cytokine secretion from RA-FLS.