Simultaneous intraocular and cutaneous extranodal NK/T cell lymphoma refractory to multiple therapies including pembrolizumab
Peter Mallal1, Benhur Ammanuel2, Rohen White3, Chris Kennedy4, Chan Yoon Cheah1,5,6
1Department of Haematology, Sir Charles Gairdner Hospital, Nedlands, WA, Australia; 2Department of Anatomical Pathology, Pathwest Laboratory Medicine, Nedlands, WA, Australia; 3Department of Radiation Oncology, Sir Charles Gairdner Hospital, Nedlands, WA, Australia;4St John of God Eye Clinic, Subiaco, WA, Australia;5Department of Haematology, Pathwest Laboratory Medicine, Nedlands, WA, Australia; 6Medical School, University of Western Australia, Crawley, WA, Australia.
corresponding author:
Peter Mallal
Department of Haematology
Sir Charles Gairdner Hospital
Hospital Avenue
Nedlands, WA, Australia
email: petermallal93@gmail.com
word count: 1776
reference count: 38
figures: 2
Keywords: Haematology, Lymphoma, ocular lymphoma, ENKL, ENKTL, Pembrolizumab
Key Clinical Message: Floaters or visual disturbance in a patient with ENKL should prompt evaluation for possible vitreoretinal involvement. Lymphoma with ocular involvement should be treated aggressively and in most cases heralds CNS involvement.