Conclusions
In our study, performed in patients with severe Hemophilia A in prophylactic treatment, platelet function was essentially normal and did not change after the infusion of FVIII. The amount of total microvesicles and those of platelet origin are significantly decreased in patients with Hemophilia A compared to healthy subjects. The administration of FVIII was accompanied with a lower amount of microvesicles of endothelial origin, suggesting that FVIII treatment does not increase the thrombotic risk in these patients. Our results do not support the use of platelet aggregation studies in patients with severe Hemophilia A.