Hemogram.
Although most hematological parameters were completely normal, we found
that administration of FVIII resulted in a lower mean platelet volume in
the HA patients and the reason is at present unknown. Since MPV was not
elevated basally in these patients, we can rule out the possibility of a
possible elevation of platelet volume to compensate for the deficit of
FVIII. Although the reduction of MPV after FVIII administration was very
modest, we are not certain about the clinical significance of this acute
effect. More studies would be necessary to elucidate this aspect.
As expected, our patients showed a very low plasma FVIII levels which
were normalized after its infusion. However, neither VWF:Ag nor VWF:Rco
exhibited differences with the control values, which is in agreement
with data reported previously (12).