Study of plasma microvesicles (MVs).
There was a lower number of total MVs in HA patients as compared to the controls and the administration of FVIII eliminated these differences (suppl, Table 8). The number of CD62+ MVs was greater in the controls than in both samples of patients. Among patients, the number of MVs of endothelial origin (CD144+) decreased significantly after the infusion of FVIII. In relation to age in patients (suppl, Table 9), there were no significant differences in the total number of MVs or in MVs of platelet origin. However, a decrease in MVs of endothelial origin (CD144+) was observed after infusion of FVIII in the younger (<18 years) patients (suppl, Table 9).