Hemogram.
Although most hematological parameters were completely normal, we found that administration of FVIII resulted in a lower mean platelet volume in the HA patients and the reason is at present unknown. Since MPV was not elevated basally in these patients, we can rule out the possibility of a possible elevation of platelet volume to compensate for the deficit of FVIII. Although the reduction of MPV after FVIII administration was very modest, we are not certain about the clinical significance of this acute effect. More studies would be necessary to elucidate this aspect.
As expected, our patients showed a very low plasma FVIII levels which were normalized after its infusion. However, neither VWF:Ag nor VWF:Rco exhibited differences with the control values, which is in agreement with data reported previously (12).