Study of plasma microvesicles (MVs).
There was a lower number of total MVs in HA patients as compared to the
controls and the administration of FVIII eliminated these differences
(suppl, Table 8). The number of CD62+ MVs was greater in the controls
than in both samples of patients. Among patients, the number of MVs of
endothelial origin (CD144+) decreased significantly after the infusion
of FVIII. In relation to age in patients (suppl, Table 9), there were no
significant differences in the total number of MVs or in MVs of platelet
origin. However, a decrease in MVs of endothelial origin (CD144+) was
observed after infusion of FVIII in the younger (<18 years)
patients (suppl, Table 9).