COVID-19 pandemic continues to spread across the world in late September
2020. To date, total cases of COVID-19 exceed 33 million including
996.342 deaths according to the WHO data. Although hydroxychloroquine,
oseltamivir, remdesivir, favipiravir have been reported as an
anti-SARS-CoV-2 effect, it is still unclear the fully effective
protective drug and treatment. Herein, we report a woman under Tenofovir
diphosphate who live and close contact with his COVID-19 positive
husband. Although she had close contact with his husband without measure
in the home she did not show any symptoms and signs of COVID-19 and her
PCR test along with antibody test negative. Given the high reproduction
number of SARS-CoV-2 and long-term close contact of the case, it can be
speculated that Tenofovir could interfere with the transmission of
COVID-19.