Covariates
Treatment exposures (e.g. individual chemotherapeutic agents and radiation) known to increase the risk of chronic health conditions in survivors were selected a priori and informed by Children’s Oncology Group guidelines version 5.0.26 Specific treatment exposures were selected for each health outcome in order to provide adequate adjustment for treatment exposures in separate models (see Table 1 for a description of treatment exposures included for each health outcome). Age at evaluation, age at cancer diagnosis, sex, race/ethnicity, body mass index (BMI) and physical inactivity were included as covariates in all models. Physical inactivity was defined as not meeting Centers for Disease Control recommendation for physical activity (75 minutes of vigorous or 150 minutes of moderate activity per week).27 Weekly moderate and vigorous activities were converted into metabolic equivalents (METS), individuals who reported <450 METS per week were classified as inactive. Age at evaluation, BMI and physical activity were assessed at the time of the sleep survey.