Parameter Treatment Day Statistic 40 mg 80 mg
n/nmiss Day 1 and 10: 9/0 Day 1: 8/0 Day 10: 7/1
AUC0-24h (nmol∙h/L) Day 1 Mean (SD) 5580 (1650) 11500 (2410)
Median (Min, Max) 5990 (3170, 8680) 1160 (8220, 16400)
Geometric mean 5360 11300
Geometric CV (%) 31.6 20.3
AUCss (nmol∙h/L) Day 10 Mean (SD) 6000 (1970) 12200 (3150)
Median (Min, Max) 5920 (3690, 9360) 11900 (8150, 18200)
Geometric mean 5730 11900
Geometric CV (%) 32.8 25.2
Cmax (nmol/L) Day 1 Mean (SD) 630 (54.0) 1490 (410)
Median (Min, Max) 630 (559, 729) 1370 (1010, 2220)
Geometric mean 628 1440
Geometric CV (%) 8.54 27.1
Day 10 Mean (SD) 567 (95.7) 1430 (393)
Median (Min, Max) 600 (438, 736) 1370 (881, 2150)
Geometric mean 560 1380
Geometric CV (%) 17.1 28.0
tmax (h) Day 1 Median (Min, Max) 2.0 (0.3, 3.0) 0.8 (0.3, 2.0)
Day 10 Median (Min, Max) 2.0 (0.7, 8.0) 2.0 (0.4, 3.0)
t1/2 (h) Day 1 Mean (SD) 6.8 (1.3) 7.1 (1.1)
Median (Min, Max) 6.3 (5.4, 9.4) 6.7 (5.7, 8.7)
Day 10 Mean (SD) 7.0 (1.4) 7.2 (0.6)
Median (Min, Max) 6.7 (4.8, 9.5) 7.3 (6.1, 8.0)
CL/F (L/h) Day 1 Mean (SD) 26.0 (9.44) 23.7 (5.12)
Median (Min, Max) 22.2 (13.5, 43.5) 23.6 (15.2, 33.3)
Geometric mean 24.6 23.2
Geometric CV (%) 36.7 22.5
Day 10 Mean (SD) 26.5 (8.1) 25.0 (6.1)
Median (Min, Max) 24.5 (15.5, 39.3) 24.4 (15.9, 35.6)
Geometric mean 25.4 24.4
Geometric CV (%) 32.8 25.2
Vz/F (L) Day 1 Mean (SD) 242 (54.5) 239 (43.0)
Median (Min, Max) 222 (183, 356) 229 (180, 301)
Geometric mean 237 236
Geometric CV (%) 20.9 18.2
Day 10 Mean (SD) 256 (53.3) 258 (63.4)
Median (Min, Max) 232 (190, 349) 250 (159, 348)
Geometric mean 251 251
Geometric CV (%) 20.2 26.5