Parameters n Isotretinoin treatment Isotretinoin treatment p-value
0th month (Basal) 3rd month
Hemoglobin (g/dl) 224 14.2 (2.1) 14.3 (1.7) 0.094
White blood cell (106/l) 224 7580 (2430) 7420 (2380) 0.250
Neutrophil (106/l) 222 4400 (1870) 3910 (1790) 0.002
Lymphocyte (106/l) 224 2330 (840) 2400 (950) 0.011
Monocytes (106/l) 222 600 (270) 590 (250) 0.778
Platelet (109/l) 224 304 (84) 311 (96) 0.216
PCT (10-2) 197 31 (9) 31 (9) 0.234
MPV (fl) 217 10.2 (1.3) 10.2 (1.3) 0.327
NLR (10-2) 222 189 (88) 161 (87) 0.001
MLR (10-2) 224 25 (15) 25 (13) 0.203
PLR 224 126.6 (53.4) 128.9 (49.3) 0.085
Total cholesterol (mg/dl) 220 161 (44) 177 (48) <0.001
HDL (mg/dl) 199 51 (17) 49 (16) <0.001
LDL (mg/dl) 220 92 (42) 108 (39) <0.001
Triglyceride (mg/dl) 220 84 (47) 106 (82) <0.001
MHR (105/mg) 198 11.9 (6.7) 12.5 (7.3) 0.042
ALT (U/l) 224 13 (7) 13 (9) 0.074
AST (U/l) 224 17 (4) 18 (5) 0.087
BUN (mg/dl) 224 13.3 ± 4.1 12.5 ± 3.9 0.156*
Creatinine (mg/dl) 224 0.75 ± 0.10 0.75 ± 0.07 0.405*
Uric acid (mg/dl) 135 4.39 ± 1.30 4.54 ± 1.38 0.010*
Data are expressed as median (interquartile range) or mean ± standard deviation for those with non-parametric or parametric distribution, respectively. *Paired sample t-test was used. Wilcoxon test was used for all others. Significant values were shown in bold. PCT: Plateletcrit; MPV: Mean platelet volume; NLR: Neutrophil/lymphocyte ratio; MLR: Monocytes/lymphocyte ratio; PLR: Platelet/lymphocyte ratio; HDL: High density lipoprotein; LDL: Low density lipoprotein; MHR: Monocytes/ high density lipoprotein ratio; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; BUN: Blood urea nitrogen Data are expressed as median (interquartile range) or mean ± standard deviation for those with non-parametric or parametric distribution, respectively. *Paired sample t-test was used. Wilcoxon test was used for all others. Significant values were shown in bold. PCT: Plateletcrit; MPV: Mean platelet volume; NLR: Neutrophil/lymphocyte ratio; MLR: Monocytes/lymphocyte ratio; PLR: Platelet/lymphocyte ratio; HDL: High density lipoprotein; LDL: Low density lipoprotein; MHR: Monocytes/ high density lipoprotein ratio; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; BUN: Blood urea nitrogen Data are expressed as median (interquartile range) or mean ± standard deviation for those with non-parametric or parametric distribution, respectively. *Paired sample t-test was used. Wilcoxon test was used for all others. Significant values were shown in bold. PCT: Plateletcrit; MPV: Mean platelet volume; NLR: Neutrophil/lymphocyte ratio; MLR: Monocytes/lymphocyte ratio; PLR: Platelet/lymphocyte ratio; HDL: High density lipoprotein; LDL: Low density lipoprotein; MHR: Monocytes/ high density lipoprotein ratio; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; BUN: Blood urea nitrogen Data are expressed as median (interquartile range) or mean ± standard deviation for those with non-parametric or parametric distribution, respectively. *Paired sample t-test was used. Wilcoxon test was used for all others. Significant values were shown in bold. PCT: Plateletcrit; MPV: Mean platelet volume; NLR: Neutrophil/lymphocyte ratio; MLR: Monocytes/lymphocyte ratio; PLR: Platelet/lymphocyte ratio; HDL: High density lipoprotein; LDL: Low density lipoprotein; MHR: Monocytes/ high density lipoprotein ratio; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; BUN: Blood urea nitrogen Data are expressed as median (interquartile range) or mean ± standard deviation for those with non-parametric or parametric distribution, respectively. *Paired sample t-test was used. Wilcoxon test was used for all others. Significant values were shown in bold. PCT: Plateletcrit; MPV: Mean platelet volume; NLR: Neutrophil/lymphocyte ratio; MLR: Monocytes/lymphocyte ratio; PLR: Platelet/lymphocyte ratio; HDL: High density lipoprotein; LDL: Low density lipoprotein; MHR: Monocytes/ high density lipoprotein ratio; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; BUN: Blood urea nitrogen