Results

Of the 244 acne patients participating in the study, 173 were women (77.2%). The mean age of the patients was 21.0 ± 3.5 years. There was no difference between genders in terms of age (p: 0.263). The changes in laboratory parameters in the 3rd month of ISO treatment compared to the 0th month are presented in Table 1. After treatment, there was a statistically decrease in neutrophil count and an increase in lymphocyte count (p: 0.002, p: 0.011; respectively). Accordingly, there was a statistically significant decrease in NLR (p: 0.001). A statistically significant increase in total cholesterol, LDL, triglyceride levels, and a significant decrease in HDL levels were found (p < 0.001). It was noteworthy that MHR and SUA levels increased significantly (p: 0.042, p: 0.010; respectively). Correlations of SUA levels with laboratory parameters before and after treatment were presented in Table 2. SUA and hemoglobin levels were moderately positively correlated (r: 0.439, p < 0.001 and r: 0.473, p < 0.001; respectively). Although there was no significant relationship between SUA level with total cholesterol, LDL, and triglyceride levels before treatment, a weakly significant relationship was found between them after treatment (Table 2). The correlation between MHR and SUA levels before and after treatment was statistically significant (r: 0.157, p: 0.048; r: 0.212, p: 0.012; respectively).