DISCUSSION
The findings of this study, the first to evaluate RV remodeling after
TMVI in patients excluded from conventional cardiac surgery due to
excessive risk, can be summarized as follows: TMVI using the
transapically tethered Tendyne mitral valve system resulted in (i)
abolition of MR with an associated immediate increase in SVI and a
reduction in LV volumes; (ii) an immediate increase in RVSWI with an
improvement in RV contractile performance as measured by RVFAC, TAPSE,
RVFWLS and RVS’; (iii) a reduction in PASP and severity of TR at
3-months. The extent of improvement in RV remodeling at 3-months in the
group with severe LV dysfunction was similar to that of the group with
less severe LV and RV dysfunction at baseline (Figure 6; Video 1 and 2).