Statistical analysis:
Reporting data was manually entered by an independent observer. All descriptive data are reported as mean±SD. A repeated-measures analysis was conducted comparing echocardiographic measures across time. After identification of an overall significant difference, all possible pairwise comparisons were made, and a Tukey adjustment was applied to control the overall type I error rate. A Wilcoxon rank-sum analysis was used to examine the difference between time intervals. Data analysis was performed with SPSS-24 (IBM Corporation, Armonk, New York).
RESULTS