Left ventricular remodeling:
MR was abolished in all patients immediately following TMVI and this was associated with a reduction in LV volumes. At 3-months no patient had >1+MR (n=46; p<0.001 vs baseline) (Table 5; Figure 4). Thirty-six patients (78%) had a LVEF <50% at baseline, and 18 patients (39%) had a LVEF ≤35%. For the entire group, indexed LVEDV (LVEDVI) and indexed LVESV (LVESVI) were elevated pre-operatively (88±24mL/m² and 54±20mL/m² respectively) (Tables 2 and 3), and decreased on discharge to 72±23mL/m² (p=0.001) and 45±17mL/m² (p=0.03), respectively (Table 5; Figure 5). The improvement in LVEDVI was sustained at 3-month follow-up (70±40 mL/m², p=0.003), but was associated with a small decline in LVEF (40±10% vs 36±15%; p=0.008) (Table 5). There was a non-significant decline in LVGLS, whilst circumferential and radial strain remained steady at 3-months presumably due to the effect of the apical tether (Table 5).