REFERENCES
1. Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, et al. A pneumonia
outbreak associated with a new coronavirus of probable bat origin.
Nature 2020; 579:270-3.
2. Grasselli G, Zangrillo A, Zanella A, Antonelli M, Cabrini L, Castelli
A, et al. Baseline Characteristics and Outcomes of 1591 Patients
Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy.
JAMA 2020.
3. Azkur AK, Akdis M, Azkur D, Sokolowska M, van de Veen W, Bruggen MC,
et al. Immune response to SARS-CoV-2 and mechanisms of
immunopathological changes in COVID-19. Allergy 2020; 75:1564-81.
4. McGonagle D, Sharif K, O’Regan A, Bridgewood C. The Role of Cytokines
including Interleukin-6 in COVID-19 induced Pneumonia and Macrophage
Activation Syndrome-Like Disease. Autoimmun Rev 2020; 19:102537.
5. Mo P, Xing Y, Xiao Y, Deng L, Zhao Q, Wang H, et al. Clinical
characteristics of refractory COVID-19 pneumonia in Wuhan, China. Clin
Infect Dis 2020.
6. Papayannopoulos V. Neutrophil extracellular traps in immunity and
disease. Nat Rev Immunol 2018; 18:134-47.
7. Lagunas-Rangel FA. Neutrophil-to-lymphocyte ratio and
lymphocyte-to-C-reactive protein ratio in patients with severe
coronavirus disease 2019 (COVID-19): A meta-analysis. J Med Virol 2020.
8. Barnes BJ, Adrover JM, Baxter-Stoltzfus A, Borczuk A, Cools-Lartigue
J, Crawford JM, et al. Targeting potential drivers of COVID-19:
Neutrophil extracellular traps. J Exp Med 2020; 217.
9. Zuo Y, Yalavarthi S, Shi H, Gockman K, Zuo M, Madison JA, et al.
Neutrophil extracellular traps in COVID-19. JCI Insight 2020; 5.
10. Gueant JL, Fromonot J, Gueant-Rodriguez RM, Lacolley P, Guieu R,
Regnault V. Blood Myeloperoxidase-DNA, a biomarker of early response to
SARS-CoV-2 infection? Allergy 2020.
11. Cortjens B, de Boer OJ, de Jong R, Antonis AF, Sabogal Pineros YS,
Lutter R, et al. Neutrophil extracellular traps cause airway obstruction
during respiratory syncytial virus disease. J Pathol 2016; 238:401-11.
12. Twaddell SH, Baines KJ, Grainge C, Gibson PG. The Emerging Role of
Neutrophil Extracellular Traps in Respiratory Disease. Chest 2019;
156:774-82.
13. Li K, Fang Y, Li W, Pan C, Qin P, Zhong Y, et al. CT image visual
quantitative evaluation and clinical classification of coronavirus
disease (COVID-19). Eur Radiol 2020; 30:4407-16.
14. Popovic B, Zannad F, Louis H, Clerc-Urmes I, Lakomy C, Gibot S, et
al. Endothelial-driven increase in plasma thrombin generation
characterising a new hypercoagulable phenotype in acute heart failure.
Int J Cardiol 2019; 274:195-201.
15. DeLong ER, DeLong DM, Clarke-Pearson DL. Comparing the areas under
two or more correlated receiver operating characteristic curves: a
nonparametric approach. Biometrics 1988; 44:837-45.
16. Efron B, Tibhirani RJ. An introduction to the bootstrap. 1994.
17. Nagelkerke NJD. A note on a general definition of the coefficient of
determination. Biometrika 1991; 78:691-2.
18. Funchal GA, Jaeger N, Czepielewski RS, Machado MS, Muraro SP, Stein
RT, et al. Respiratory syncytial virus fusion protein promotes
TLR-4-dependent neutrophil extracellular trap formation by human
neutrophils. PLoS One 2015; 10:e0124082.
19. Pillai PS, Molony RD, Martinod K, Dong H, Pang IK, Tal MC, et al.
Mx1 reveals innate pathways to antiviral resistance and lethal influenza
disease. Science 2016; 352:463-6.
20. Bendib I, de Chaisemartin L, Mekontso Dessap A, Chollet-Martin S, de
Prost N. Understanding the Role of Neutrophil Extracellular Traps in
Patients With Severe Pneumonia and ARDS. Chest 2019; 156:1278-80.
21. Granger V, Faille D, Marani V, Noel B, Gallais Y, Szely N, et al.
Human blood monocytes are able to form extracellular traps. J Leukoc
Biol 2017; 102:775-81.
22. Kettritz R. Neutral serine proteases of neutrophils. Immunol Rev
2016; 273:232-48.
23. Lengas A, Poletti V, Pacifico L, di Domizio C, Patelli M, Spiga L.
Acute lung inflammation: neutrophil elastase versus neutrophils in the
bronchoalveolar lavage–neutrophil elastase reflects better
inflammatory intensity. Intensive Care Med 1994; 20:354-9.
24. Polverino E, Rosales-Mayor E, Dale GE, Dembowsky K, Torres A. The
Role of Neutrophil Elastase Inhibitors in Lung Diseases. Chest 2017;
152:249-62.
25. Korkmaz B, Moreau T, Gauthier F. Neutrophil elastase, proteinase 3
and cathepsin G: physicochemical properties, activity and
physiopathological functions. Biochimie 2008; 90:227-42.
26. Faurschou M, Borregaard N. Neutrophil granules and secretory
vesicles in inflammation. Microbes Infect 2003; 5:1317-27.
27. Papayannopoulos V, Metzler KD, Hakkim A, Zychlinsky A. Neutrophil
elastase and myeloperoxidase regulate the formation of neutrophil
extracellular traps. J Cell Biol 2010; 191:677-91.
28. Kolaczkowska E, Jenne CN, Surewaard BG, Thanabalasuriar A, Lee WY,
Sanz MJ, et al. Molecular mechanisms of NET formation and degradation
revealed by intravital imaging in the liver vasculature. Nat Commun
2015; 6:6673.
29. Taylor S, Dirir O, Zamanian RT, Rabinovitch M, Thompson AAR. The
Role of Neutrophils and Neutrophil Elastase in Pulmonary Arterial
Hypertension. Front Med (Lausanne) 2018; 5:217.
30. Nakazawa D, Marschner JA, Platen L, Anders HJ. Extracellular traps
in kidney disease. Kidney Int 2018; 94:1087-98.
31. Doring Y, Libby P, Soehnlein O. Neutrophil Extracellular Traps
Participate in Cardiovascular Diseases: Recent Experimental and Clinical
Insights. Circ Res 2020; 126:1228-41.
32. Bronze-da-Rocha E, Santos-Silva A. Neutrophil Elastase Inhibitors
and Chronic Kidney Disease. Int J Biol Sci 2018; 14:1343-60.
33. Alam SR, Newby DE, Henriksen PA. Role of the endogenous elastase
inhibitor, elafin, in cardiovascular injury: from epithelium to
endothelium. Biochem Pharmacol 2012; 83:695-704.
34. Clancy DM, Henry CM, Sullivan GP, Martin SJ. Neutrophil
extracellular traps can serve as platforms for processing and activation
of IL-1 family cytokines. FEBS J 2017; 284:1712-25.
35. Alfaidi M, Wilson H, Daigneault M, Burnett A, Ridger V, Chamberlain
J, et al. Neutrophil elastase promotes interleukin-1beta secretion from
human coronary endothelium. J Biol Chem 2015; 290:24067-78.
36. Korkmaz B, Horwitz MS, Jenne DE, Gauthier F. Neutrophil elastase,
proteinase 3, and cathepsin G as therapeutic targets in human diseases.
Pharmacol Rev 2010; 62:726-59.
37. Ackermann M, Verleden SE, Kuehnel M, Haverich A, Welte T, Laenger F,
et al. Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis
in Covid-19. N Engl J Med 2020; 383:120-8.
38. Bikdeli B, Madhavan MV, Jimenez D, Chuich T, Dreyfus I, Driggin E,
et al. COVID-19 and Thrombotic or Thromboembolic Disease: Implications
for Prevention, Antithrombotic Therapy, and Follow-Up: JACC
State-of-the-Art Review. J Am Coll Cardiol 2020; 75:2950-73.
39. Driggin E, Madhavan MV, Bikdeli B, Chuich T, Laracy J, Biondi-Zoccai
G, et al. Cardiovascular Considerations for Patients, Health Care
Workers, and Health Systems During the COVID-19 Pandemic. J Am Coll
Cardiol 2020; 75:2352-71.
40. Babapoor-Farrokhran S, Gill D, Walker J, Rasekhi RT, Bozorgnia B,
Amanullah A. Myocardial injury and COVID-19: Possible mechanisms. Life
Sci 2020; 253:117723.
41. Doyen D, Moceri P, Ducreux D, Dellamonica J. Myocarditis in a
patient with COVID-19: a cause of raised troponin and ECG changes.
Lancet 2020; 395:1516.
42. Renu K, Prasanna PL, Valsala Gopalakrishnan A. Coronaviruses
pathogenesis, comorbidities and multi-organ damage - A review. Life Sci
2020; 255:117839.
43. Libby P. The Heart in COVID19: Primary Target or Secondary
Bystander? JACC Basic Transl Sci 2020.
44. Hassanein M, Thomas G, Taliercio J. Management of acute kidney
injury in COVID-19. Cleve Clin J Med 2020.
45. Oussalah A, Gleye S, Clerc Urmes I, Laugel E, Callet J, Barbé F, et
al. Long-term ACE Inhibitor/ARB Use Is Associated With Severe Renal
Dysfunction and Acute Kidney Injury in Patients With Severe COVID-19:
Results From a Referral Center Cohort in the Northeast of France.
Clinical Infectious Diseases 2020.
46. Cheng Y, Luo R, Wang K, Zhang M, Wang Z, Dong L, et al. Kidney
disease is associated with in-hospital death of patients with COVID-19.
Kidney International 2020; 97:829-38.
47. Liu T, Zhang J, Yang Y, Ma H, Li Z, Zhang J, et al. The role of
interleukin-6 in monitoring severe case of coronavirus disease 2019.
EMBO Molecular Medicine 2020; 12:e12421.
48. Del Valle DM, Kim-Schulze S, Hsin-Hui H, Beckmann ND, Nirenberg S,
Wang B, et al. An inflammatory cytokine signature helps predict COVID-19
severity and death. medRxiv 2020.
49. Roschewski M, Lionakis MS, Sharman JP, Roswarski J, Goy A,
Monticelli MA, et al. Inhibition of Bruton tyrosine kinase in patients
with severe COVID-19. Sci Immunol 2020; 5.
50. Uddin M, Watz H, Malmgren A, Pedersen F. NETopathic Inflammation in
Chronic Obstructive Pulmonary Disease and Severe Asthma. Front Immunol
2019; 10:47.
51. Didangelos A. COVID-19 Hyperinflammation: What about Neutrophils?
mSphere 2020; 5:e00367-20.
52. Colafrancesco S, Alessandri C, Conti F, Priori R. COVID-19 gone bad:
A new character in the spectrum of the hyperferritinemic syndrome?
Autoimmun Rev 2020; 19:102573.
53. Takeshita H, Yasuda T, Nakajima T, Hosomi O, Nakashima Y, Kishi K.
Mouse deoxyribonuclease I (DNase I): biochemical and immunological
characterization, cDNA structure and tissue distribution. Biochem Mol
Biol Int 1997; 42:65-75.
54. Ueki M, Takeshita H, Fujihara J, Iida R, Yuasa I, Kato H, et al.
Caucasian-specific allele in non-synonymous single nucleotide
polymorphisms of the gene encoding deoxyribonuclease I-like 3,
potentially relevant to autoimmunity, produces an inactive enzyme. Clin
Chim Acta 2009; 407:20-4.
55. Ueki M, Kimura-Kataoka K, Takeshita H, Fujihara J, Iida R, Sano R,
et al. Evaluation of all non-synonymous single nucleotide polymorphisms
(SNPs) in the genes encoding human deoxyribonuclease I and I-like 3 as a
functional SNP potentially implicated in autoimmunity. The FEBS Journal
2014; 281:376-90.
56. Keyel PA. Dnases in health and disease. Dev Biol 2017; 429:1-11.
57. Jimenez-Alcazar M, Rangaswamy C, Panda R, Bitterling J, Simsek YJ,
Long AT, et al. Host DNases prevent vascular occlusion by neutrophil
extracellular traps. Science 2017; 358:1202-6.
58. Chen D, Yang XL, Shen ZB, Sun XM, Guo Q, Ren YH, et al.
[Significance of neutrophil extracellular trap and its markers in the
early diagnosis of community-acquired pneumonia in children]. Zhongguo
Dang Dai Er Ke Za Zhi 2019; 21:868-75.
59. Denning NL, Aziz M, Gurien SD, Wang P. DAMPs and NETs in Sepsis.
Front Immunol 2019; 10:2536.
60. Zitter JN, Maldjian P, Brimacombe M, Fennelly KP. Inhaled Dornase
alfa (Pulmozyme) as a noninvasive treatment of atelectasis in
mechanically ventilated patients. J Crit Care 2013; 28:218 e1-7.
61. Pottecher J, Noll E, Borel M, Audibert G, Gette S, Meyer C, et al.
Protocol for TRAUMADORNASE: a prospective, randomized, multicentre,
double-blinded, placebo-controlled clinical trial of aerosolized dornase
alfa to reduce the incidence of moderate-to-severe hypoxaemia in
ventilated trauma patients. Trials 2020; 21:274.
62. Fuchs TA, Jimenez-Alcazar M, Göbel J, Englert H. Engineered DNAse
enzymes and use in therapy. 2019.