Results
A two-compartment model with sequential zero-first order absorption and
first-order elimination reasonably described yimitasvir pharmacokinetics
(PK). The apparent oral clearance and central volume of distribution
were 13.8 l h-1 and 188 l, respectively. The
bioavailability (F) of yimitasvir decreased 12.9% for each 100 mg dose
increase. Food was found to affect absorption rate (Ka) and F. High-fat
meal decreased Ka and F by 90.9% and 38.5%, respectively. Gender and
alanine aminotransferase were identified as significant covariates on
apparent oral clearance. Female subjects had lower clearance than male
subjects. Zero-order absorption duration was longer in healthy
volunteers (2.17 h) than that in patients (1.43 h).