References
1. Etzioni DA, Starnes VA. The epidemiology and economics of
cardiothoracic surgery in the elderly. In: Katlic MR, editor.
Cardiothoracic surgery in the elderly: evidence-based practice. New
York: Springer 2011;5-24.
2. Benjamin EJ, Muntner P, Alonso, A, et al. Heart Disease and Stroke
Statistics-2019 Update: A Report From the American Heart Association
Circulation 2019;139:e56–e528.
3. Adamo M, Capodanno D, Cannata S, et al. Comparison of three
contemporary surgical scores for predicting all-cause mortality of
patients undergoing percutaneous mitral valve repair with the MitraClip
system (from the multicenter GRASP-IT registry). American Journal of
Cardiology 2015;115(1):107-112.
4. Kaartama T, Heikkinen L, Vento A. An evaluation of mitral valve
procedures using the European system for cardiac operative risk
evaluation. Scandinavian Journal of Surgery 2008;97(3):254-258.
5. Barili F, Pacini D, Grossi C, Di Bartolomeo R, Alamanni F, Parolari
A. Reliability of new scores in predicting perioperative mortality after
mitral valve surgery. Journal of Thoracic and Cardiovascular Surgery
2014;147(3):1008-1012.
6. Jamieson WR, Edwards FH, Schwartz M, Bero JW, Clark RE, Grover FL.
Risk stratification for cardiac valve replacement. national cardiac
surgery database. Database committee of the society of thoracic
surgeons. The Annals of thoracic surgery 1999;67:943.
7. Wang TKM, Harmos S, Gamble GD, Ramanathan T, Ruygrok PN. Performance
of contemporary surgical risk scores for mitral valve surgery. Journal
of Cardiac Surgery 2017;32:172-6.
8. EUGenMed Cardiovascular Clinical Study Group, Regitz-Zagrosek V,
Oertelt-Prigione S, et al. Gender in cardiovascular diseases: impact on
clinical manifestations, management, and outcomes. European Heart
Journal 2016;37(1):24-34.
9. Saad M, Nairooz R, Pothineni NVK, et al. Long-Term Outcomes With
Transcatheter Aortic Valve Replacement in Women Compared With Men:
Evidence From a Meta-Analysis. Journal of the American College of
Cardiology: Cardiovascular Interventions 2018;11(1):24-35.
10. Nishimura R, Otto C, Bonow R, et al. 2017 AHA/ACC focused update of
the 2014 AHA/ACC guideline for the management of patients with valvular
heart disease: A report of the american college of cardiology/american
heart association task force on clinical practice guidelines.
Circulation 2017;135:e1159-95.
11. Giustino G, Overbey J, Taylor D, et al. Sex-based differences in
outcomes after mitral valve surgery for severe ischemic mitral
regurgitation: From the cardiothoracic surgical trials network. Journal
of the American College of Cardiology 2019;73:1951.
12. Vassileva CM, MD, McNeely C, BS, Mishkel G, MD, Boley T, MSN,
Markwell S, MA, Hazelrigg S, MD. Gender differences in long-term
survival of medicare beneficiaries undergoing mitral valve operations.
Annals of Thoracic Surgery 2013;96:1367-73.
13. Vassileva CM, Stelle LM, Markwell S, Boley T, Hazelrigg S. Sex
differences in procedure selection and outcomes of patients undergoing
mitral valve surgery. The Heart Surgery Forum 2011;14(5):E276-E282.
14. Johnston A, Mesana TG, Lee DS, Eddeen AB, Sun LY. Sex Differences in
Long-Term Survival After Major Cardiac Surgery: A Population-Based
Cohort Study. Journal of the American Heart Association
2019;8(17):e013260.
15. Mokhles MM, Siregar S, Versteegh MI, et al. Male-female differences
and survival in patients undergoing isolated mitral valve surgery: a
nationwide cohort study in the Netherlands. European Journal of
Cardiothoracic Surgery 2016;50(3):482-487.
16. Jung JC, Jang MJ, Hwang HY. Meta-Analysis Comparing Mitral Valve
Repair Versus Replacement for Degenerative Mitral Regurgitation Across
All Ages. American Journal of Cardiology 2019;123(3):446-453.
17. Yun-Dan D, Wen-Jing D, Xi-Jun X. Comparison of Outcomes following
Mitral Valve Repair versus Replacement for Chronic Ischemic Mitral
Regurgitation: A Meta-Analysis. The Journal of Thoracic and
Cardiovascular Surgery 2017;65(6):432-441.
18. Song HK, Grab JD, O’Brien SM, Welke KF, Edwards F, Ungerleider RM.
Gender differences in mortality after mitral valve operation: evidence
for higher mortality in perimenopausal women. The Annuals of Thoracic
Surgery 2008;85(6):2040-2045.
19. Gammie JS, Sheng S, Griffith BP, et al. Trends in mitral valve
surgery in the united states: Results from the society of thoracic
surgeons adult cardiac surgery database. The Annals of thoracic surgery
2009;87:1431.
20. Azevedo PS, Polegato BF, Minicucci MF, Paiva SAR, Zornoff LAM.
Cardiac remodeling: Concepts, clinical impact, pathophysiological
mechanisms and pharmacologic treatment. Arquivos brasileiros de
cardiologia 2016;106:62-9.
21. Wu Q, Xiao Y, Yuan Y, et al. Mechanisms contributing to cardiac
remodelling. Clinical science (1979) 2017;131:2319-45.
22. Goldstein D, Moskowitz AJ, Gelijns AC, et al. Two-Year Outcomes of
Surgical Treatment of Severe Ischemic Mitral Regurgitation. N Engl J
Med. 2016;374(4):344-353. doi:10.1056/NEJMoa1512913
23. Abd Elaziz ME, Ibrahim IM. Reversal of Left Ventricular Functions in
Chronic Mitral Regurgitation after Mitral Valve Replacement. Heart Surg
Forum. 2016;19(4):E160-E164.
24. Lazam S, Vanoverschelde JL, Tribouilloy C, Grigioni F, Suri RM,
Avierinos JL, de Meester C, Barbieri A, Rusinaru D, Russo A, Pasquet A,
Michelena H, Huebnner M, Maalouuff J, Clavel MA, Szymanski C,
Enriquez-Sarano M. Twenty-Year Outcome after Mitral Repair Versus
Replacement for Severe Degenerative Mitral Regurgitation. Analysis of a
Large, Prospective, Multicenter International Registry. Circulation
2017;135(5):410-422.
25. Mick SL, Keshavamurthy S, and Gillinov AM. Mitral valve repair
versus replacement. Ann Cardiothorac Surg. 2015;4(3):230–237.
26. Hendrix RJ, Bello RA, Flahive JM, et al. Mitral Valve Repair Versus
Replacement in Elderly With Degenerative Disease: Analysis of the STS
Adult Cardiac Surgery Database. Ann Thorac Surg. 2019;107(3):747-753.
doi:10.1016/j.athoracsur.2018.09.018
27. Tran A, Ruel M, Chan V. Gender differences in outcomes following
cardiac surgery: implications for managing patients with mitral valve
disease. Current Opinion in Cardiology 2015;30(2):151-154.
28. Nagendran J, Nagendran J, Bozso SJ, et al. Coronary artery bypass
surgery improves outcomes in patients with diabetes and Left Ventricular
dysfunction. Journal of the American College of Cardiology
2018;71:819-27.
29. O’Brien SM, Feng L, He X, et al. The society of thoracic surgeons
2018 Adult cardiac surgery risk models: Part 2—Statistical methods and
Results. The Annals of Thoracic Surgery 18;105:1419-28.
30. Fine JP, Gray RJ. A proportional hazards model for the
subdistribution of a competing risk. J Am Stat Assoc 1999;94:496-509.
31. Kislitsina ON, Zareba KM, Bonow RO, et al. Is mitral valve disease
treated differently in men and women? European Journal of Preventive
Cardiology 2019;26:1433-43.
32. McNeely C, Vassileva C. Mitral valve surgery in women: Another
target for eradicating sex inequality. Circulation. Cardiovascular
quality and outcomes 2016;9:S94-6.
Figure 1. Study Population Flowchart