RESULTS
In the present work, we aimed to assess the contribution of thePLCB1 gene in the different stages of cocaine addiction using
heterozygous knockout mice (Plcb1+/- ). To do so, we performed a
general phenotypic characterization and, then we evaluated cocaine
operant self-administration, extinction, and cue-induced reinstatement
in those animals. Also, we studied transcriptional changes in mPFC and
HPC to understand the mechanisms involved.