RESULTS
In the present work, we aimed to assess the contribution of thePLCB1 gene in the different stages of cocaine addiction using heterozygous knockout mice (Plcb1+/- ). To do so, we performed a general phenotypic characterization and, then we evaluated cocaine operant self-administration, extinction, and cue-induced reinstatement in those animals. Also, we studied transcriptional changes in mPFC and HPC to understand the mechanisms involved.