Figure 1.
Regulation of IgE binding to CD23. A) Free IgE binds only weakly CD23
monomer whereas it binds much more strongly to oligomerized CD23 B)
IgE-antigen immune complexes (IgE-IC) bind to CD23 much stronger than
free IgE C) Binding of antigen-specific IgG to IgE-antigen complexes
could enable complement fixation via CD21 and lead to co-aggregation of
CD23 and CD21.