Table 1 shows the summary data for the variants that proxy IL-6
signalling inhibition. SNP: single nucleotide polymorphism. Beta is the
unit change in natural log transformed CRP (mg/L) per copy increment in
the effect allele. R2 represents the variance in CRP
explained by the respective genetic variant. F-statistic measures the
strength of the instrumental variable with the exposure. Variants
identified and associated well with IL-6 signalling inhibition in a
previous Mendelian randomization study exploring IL-6 inhibition and
effects on ischaemic stroke and cardiovascular
outcomes.8