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Legend: The determinations were realized in serum samples gotten after
euthanasia. The results represent the medium ± στανδαρδ δεϖιατιον οφ
8−10 δετερμινατιον περ τρεατμεντ. ΑΝΟςΑ ωασ δετερμινεδ ωιτη α
σιγνιφιχανχε οφ π<0,05.
However, these results suggest that its action could be related to the
reduction of the concentration of atherogenic lipoproteins in the serum
of these animals, which can be justified by its increase in the glycemic
control of these animals, as previously observed (Graph 3). [Salles,
da Silva, Taniguthi, Ferreira, da Rocha, Vilegas., Dias, Pennacchi,
Duarte, Rodrigues, Brigagão & Paula. 2020] reports that recent
studies have shown that the combined treatment with estatines and
phytopharmaceuticals, have been capable to decrease the levels of the
glycated hemoglobin, triglycerides, total cholesterol and LDL
cholesterol in individuals between 40 and 60 of age with type 2 diabetes
mellitus [Kianbakht, Nabati & Abasi. 2016]. In this same study, the
quantification of the amount of flavonoids, total polyphenols and
quercetin, were attributed as the mainly responsible for the observed
effects. However can not be discarded the fact that the reduction of the
triglycerides and cholesterol is linked to the reduction of glucose,
once it acts on the entire glycemic profile.
The artichoke is cited [Gonçalves, Moura, Rabelo, Barbosa-Filho, Cruz
& Cruz. 2000] as being capable of reducing the levels of lipids in
plasma.[Lorenzi & Matos. 2020], clinical trials in humans with the
intake of substances content in artichoke leafs promoted an acute
reduction of triglycerides levels. As described by [Anjo. 2004],
substances such as insulin and fructooligosaccharide present in
artichokes present effects as reducing the triglycerides levels.
Considering that the protein glycation has been pointed as one of the
main mechanisms responsible for the glomerular lesions observed at
diabetic nephropathy [Faria. 2001] serum creatinine levels in serum
in animals from different groups in the study were evaluated (Graph 5).
A significant increase in serum creatinine levels in the group of
diabetic animals non-treated with artichoke extracts when compared to
non-diabetic animals. No significant difference was observed in relation
to the serum levels of creatinine when these two groups were compared.
Graph 5. Effect of artichoke extract on creatinine levels in diabetic
rats