Font: Authored by the author
Legend: The determinations were realized in serum samples gotten after euthanasia. The results represent the medium ± στανδαρδ δεϖιατιον οφ 8−10 δετερμινατιον περ τρεατμεντ. ΑΝΟςΑ ωασ δετερμινεδ ωιτη α σιγνιφιχανχε οφ π<0,05.
However, these results suggest that its action could be related to the reduction of the concentration of atherogenic lipoproteins in the serum of these animals, which can be justified by its increase in the glycemic control of these animals, as previously observed (Graph 3). [Salles, da Silva, Taniguthi, Ferreira, da Rocha, Vilegas., Dias, Pennacchi, Duarte, Rodrigues, Brigagão & Paula. 2020] reports that recent studies have shown that the combined treatment with estatines and phytopharmaceuticals, have been capable to decrease the levels of the glycated hemoglobin, triglycerides, total cholesterol and LDL cholesterol in individuals between 40 and 60 of age with type 2 diabetes mellitus [Kianbakht, Nabati & Abasi. 2016]. In this same study, the quantification of the amount of flavonoids, total polyphenols and quercetin, were attributed as the mainly responsible for the observed effects. However can not be discarded the fact that the reduction of the triglycerides and cholesterol is linked to the reduction of glucose, once it acts on the entire glycemic profile.
The artichoke is cited [Gonçalves, Moura, Rabelo, Barbosa-Filho, Cruz & Cruz. 2000] as being capable of reducing the levels of lipids in plasma.[Lorenzi & Matos. 2020], clinical trials in humans with the intake of substances content in artichoke leafs promoted an acute reduction of triglycerides levels. As described by [Anjo. 2004], substances such as insulin and fructooligosaccharide present in artichokes present effects as reducing the triglycerides levels.
Considering that the protein glycation has been pointed as one of the main mechanisms responsible for the glomerular lesions observed at diabetic nephropathy [Faria. 2001] serum creatinine levels in serum in animals from different groups in the study were evaluated (Graph 5). A significant increase in serum creatinine levels in the group of diabetic animals non-treated with artichoke extracts when compared to non-diabetic animals. No significant difference was observed in relation to the serum levels of creatinine when these two groups were compared.
Graph 5. Effect of artichoke extract on creatinine levels in diabetic rats