Font: Authored by the author
Legend: The results represent the medium ± standard deviation of 8-10
determinations per treatment, estimated of serum levels of fructosamine.
ANOVA was determined and the letters indicate that there was significant
difference of Tukey-Kramer test, adopting p<0,05.
The hyperglycemic, with consequent increase in ROS, reduces the levels
of nitric oxide (NO) by activating the aldose reductase. The increase in
the flow through the polyols route, induced by the increase in ROS,
determines higher conversion of glucose to sorbitol, reducing NADPH and
glutathione (intracellular antioxidant) and increasing the oxidative
stress induced by hyperglycemia. Sorbitol is converted to fructose,
resulting in an increase in the NADH : NAD+ ratio,
which would increase the synthesis de diacylglycerol (DAG), the main
physiological activator of protein kinase C (PKC) [Reis, Veloso,
Mattos, Purish & Nogueira. 2008].
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