Figure 4. Change of Potential Energy during the Initializations
and Optimization.
The change of potential energy during the initial structure generation
and further iterative optimization is shown in blue line. The potential
energy shows drastic fluctuations during the initialization of
cotranslational folding which partly indicates that addition of amino
acid is not always either favorable or unfavorable. This fluctuation is
different from following iterative optimizations reflecting the strong
effect of the change of configurations. During the optimization
processes, the potential energy decreased with saltatory tendency. After
three iterations of optimizations, the potential energy remained as
being rather conserved indicating the fast convergence of the algorithm
to the local energy minima.