Diagnosis and classification
The morphology of bone marrow and peripheral blood was reviewed following Wright-Giemsa staining and classified according to the French-American-British (FAB) classification. Immunophenotype was analyzed by flow cytometry. The cytogenetics was established by chromosome banding combined with fluorescence in situ hybridization (FISH) [7]. The diagnosis of AE-AML was made based on WHO 2016 classification [10]. EML included extramedullary infiltration (EMI) and central central nervous system leukemia (CNSL), which was defined according to the previous report by Støve HK et al [11].