Conclusion
AML-M2 was the dominant morphology in AE-AML. The incidence of EML and
c-KIT mutations were much higher in adult patients and adversely
affected the disease outcome in this group of patients, suggesting
AML1-ETO fusion gene might behave differently in adults and children.
While the intensive induction and consolidation therapy were considered
to benefit patients of AE-AML regardless of age, their use have not
improved the prognosis of adult patients either presenting with EML or
harboring a c-KIT mutation. Studies are required in the future to
explore the underlying pathogenesis of EML and c-KIT mutation in
pediatric and adult AE-AML.