Patient characteristics
A total of 173 newly diagnosed AE-AML patients from Nanfang Hospital, Southern Medical University, Sun Yat-sen Memorial Hospital Sun Yat-sen University, Zhujiang Hospital, Southern Medical University, The First Affiliated Hospital of Guangzhou Medical University and Guangzhou Women and Children’s Medical Center in Guangzhou, China from January 2006 to December 2017 were retrospectively reviewed. Seventy five were children (≤14-year old) and 98 were adults (>14 years old). Patients’ clinical features were shown in Table 1. All tissue samples and clinical data were obtained upon the approval of Medicine Institutional Review Boards of related centers. Written informed consent was obtained from all patients and/or guardians.