Acknowledgments

We would like to thank the patients who participated in this study. Medical writing support was provided by Mahalia Gilmartin, PhD and India Wright, MSc, and editorial support was provided by Rachael Cazaly, BSc, all of Core Medica, London, UK, supported by AstraZeneca according to Good Publication Practice guidelines (link). The sponsor was involved in the study design and collection, analysis and interpretation of data, as well as data checking of information provided in the manuscript. However, ultimate responsibility for opinions, conclusions and data interpretation lies with the authors. Development of this manuscript was supported by AstraZeneca.

Disclosures

E. Palaka, N. Guzman, A. Dunn, E.T. Wittbrodt and S. Grandy are employees and stockholders of AstraZeneca. F.O. Finkelstein has received consultation fees from AstraZeneca, GSK,and Akebia.

Author contributions

A. Dunn, S. Grandy, E. Palaka and E.T. Wittbrodt contributed to the study design and data collection. E.T. Wittbrodt, E. Palaka, F.O. Finkelstein, N. Guzman and S. Grandy performed the data analysis and interpretation. All authors critically reviewed the manuscript, approved the final version, and accept accountability for the overall work.

Data sharing statement

Data underlying the findings described in this manuscript may be obtained in accordance with AstraZeneca’s data sharing policy described at: https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure.