| Average Symptom Duration |
Average Symptom Duration |
5.1 |
9.0 |
9.0 |
0.06 |
0.06 |
0.06 |
| Average Age of Subjects |
Average Age of Subjects |
51.6 |
53.0 |
53.0 |
0.69 |
0.69 |
0.69 |
| Average UAS7(Visit 2) ±SE |
Average UAS7(Visit 2) ±SE |
26±3 |
37±5 |
37±5 |
0.12 |
0.12 |
0.12 |
| Average UAS7(Visit 5) ±SE |
Average UAS7(Visit 5) ±SE |
7±3 |
38±4 |
38±4 |
0.0003 |
0.0003 |
0.0003 |
| Average ΔUAS7(Visit 5 – Visit 2) |
Average ΔUAS7(Visit 5 – Visit 2) |
-84% |
+7.5% |
+7.5% |
0.0009 |
0.0009 |
0.0009 |
| Parameter |
Comparison Group-Visit |
Comparison Group-Visit |
Comparison Group-Visit |
Absolute Value ±SE |
Absolute Value ±SE |
Mean
difference ±SE |
Adj. P |
| UAS7* |
(Responder-Visit 1) vs. (Non-Responder-Visit 1) |
(Responder-Visit 1) vs. (Non-Responder-Visit 1) |
(Responder-Visit 1)
vs. (Non-Responder-Visit 1) |
26±3 vs. 37±5 |
26±3 vs. 37±5 |
-11±7 |
0.7 |
|
(Responder-Visit 5) vs. (Non-Responder-Visit 5) |
(Responder-Visit 5)
vs. (Non-Responder-Visit 5) |
(Responder-Visit 5) vs.
(Non-Responder-Visit 5) |
7±3 vs. 38±4 |
7±3 vs. 38±4 |
-31±7 |
0.003 |
| Blood Neutrophil % |
(Responder-Visit 1) vs. (Non-Responder-Visit 1) |
(Responder-Visit 1) vs. (Non-Responder-Visit 1) |
(Responder-Visit 1)
vs. (Non-Responder-Visit 1) |
57±3 vs. 49±6 |
57±3 vs. 49±6 |
8±7 |
0.7 |
|
(Responder-Visit 5) vs. (Non-Responder-Visit 5) |
(Responder-Visit 5)
vs. (Non-Responder-Visit 5) |
(Responder-Visit 5) vs.
(Non-Responder-Visit 5) |
59±3 vs. 62±5 |
59±3 vs. 62±5 |
-3.0±5 |
0.9 |
| Blood Eosinophil % |
(Responder-Visit 1) vs. (Non-Responder-Visit 1) |
(Responder-Visit 1) vs. (Non-Responder-Visit 1) |
(Responder-Visit 1)
vs. (Non-Responder-Visit 1) |
2±0 vs. 8±1 |
2±0 vs. 8±1 |
-6±1 |
0.001 |
|
(Responder-Visit 5) vs. (Non-Responder-Visit 5) |
(Responder-Visit 5)
vs. (Non-Responder-Visit 5) |
(Responder-Visit 5) vs.
(Non-Responder-Visit 5) |
0±0 vs. 0±1 |
0±0 vs. 0±1 |
0±1 |
1.00 |
|
(Non-Responder-Visit 1) vs. (Non-Responder-Visit 5) |
(Non-Responder-Visit 1) vs. (Non-Responder-Visit 5) |
(Non-Responder-Visit 1) vs. (Non-Responder-Visit 5) |
8±1 vs. 0±1 |
8±1
vs. 0±1 |
8±1 |
0.006 |
|
(Responder-Visit 1) vs. (Responder-Visit 5) |
(Responder-Visit 1) vs.
(Responder-Visit 5) |
(Responder-Visit 1) vs. (Responder-Visit 5) |
2±0
vs. 0±0 |
2±0 vs. 0±0 |
2±0 |
0.02 |
| Blood Lymphocyte % |
(Responder-Visit 1) vs. (Non-Responder-Visit 1) |
(Responder-Visit 1) vs. (Non-Responder-Visit 1) |
(Responder-Visit 1)
vs. (Non-Responder-Visit 1) |
31±3 vs. 34±6 |
31±3 vs. 34±6 |
-3±7 |
0.98 |
|
(Responder-Visit 5) vs. (Non-Responder-Visit 5) |
(Responder-Visit 5)
vs. (Non-Responder-Visit 5) |
(Responder-Visit 5) vs.
(Non-Responder-Visit 5) |
33±3 vs. 29±5 |
33±3 vs. 29±5 |
3±6 |
0.95 |
|
(Non-Responder-Visit 1) vs. (Non-Responder-Visit 5) |
(Non-Responder-Visit 1) vs. (Non-Responder-Visit 5) |
(Non-Responder-Visit 1) vs. (Non-Responder-Visit 5) |
34±6 vs. 29±5 |
34±6 vs. 29±5 |
5±6 |
0.88 |
|
(Responder-Visit 1) vs. (Responder-Visit 5) |
(Responder-Visit 1) vs.
(Responder-Visit 5) |
(Responder-Visit 1) vs. (Responder-Visit 5) |
31±3
vs. 33±3 |
31±3 vs. 33±3 |
-2±3 |
0.94 |
| Blood Basophil % |
(Responder-Visit 1) vs. (Non-Responder-Visit 1) |
(Responder-Visit 1) vs. (Non-Responder-Visit 1) |
(Responder-Visit 1)
vs. (Non-Responder-Visit 1) |
0.3±0.1 vs. 1.5±0.2 |
0.3±0.1 vs. 1.5±0.2 |
-1.2±0.2 |
0.02 |
|
(Responder-Visit 5) vs. (Non-Responder-Visit 5) |
(Responder-Visit 5)
vs. (Non-Responder-Visit 5) |
(Responder-Visit 5) vs.
(Non-Responder-Visit 5) |
0.4±0.1 vs. 0.2±0.1 |
0.4±0.1 vs. 0.2±0.1 |
0.2±0.2 |
0.88 |
|
(Non-Responder-Visit 1) vs. (Non-Responder-Visit 5) |
(Non-Responder-Visit 1) vs. (Non-Responder-Visit 5) |
(Non-Responder-Visit 1) vs. (Non-Responder-Visit 5) |
1.5±0.2 vs.
0.2±0.1 |
1.5±0.2 vs. 0.2±0.1 |
1.3±0.2 |
0.05 |
|
(Responder-Visit 1) vs. (Responder-Visit 5) |
(Responder-Visit 1) vs.
(Responder-Visit 5) |
(Responder-Visit 1) vs. (Responder-Visit 5) |
0.3±0.1 vs. 0.4±0.1 |
0.3±0.1 vs. 0.4±0.1 |
-0.1±0.1 |
0.93 |