Instruction
Hepatoblastoma is the most common primary tumor of the liver in
children, accounting for nearly 80% of pediatric malignant liver
tumor[1]. With the development of multimodal
treatment approaches combining platinum based (neo-)adjuvant
chemotherapy and surgery, the overall survival (OS) rates have now
reached over 80% for patients advanced
disease[2-4], but complete resection is crucial
for cure in the treatment of hepatoblastoma[5, 6].
The post-treatment extent of disease (POST-TEXT) staging was commonly
used for assessing the tumor extension after neoadjuvant chemotherapy
and evaluating tumor resectability[7]. It was a
great challenge in the treatment of POST-TEXT III and IV hepatoblastoma
and primary liver transplantation was recommended as surgical option for
these patients because of the excellent outcomes[8,
9]. In recent years, a few studies results had showed that
non-transplant hepatic resections can achieve similar outcomes with
liver transplantation in some selected POST-TEXT III and IV
patients[10-13].
The purpose of this study is to evaluate the results of extended hepatic
resection in POST-TEXT III and IV hepatoblastoma patients at a Chinese
National Children’s Medical Center with long-term follow-up.