Instruction
Hepatoblastoma is the most common primary tumor of the liver in children, accounting for nearly 80% of pediatric malignant liver tumor[1]. With the development of multimodal treatment approaches combining platinum based (neo-)adjuvant chemotherapy and surgery, the overall survival (OS) rates have now reached over 80% for patients advanced disease[2-4], but complete resection is crucial for cure in the treatment of hepatoblastoma[5, 6]. The post-treatment extent of disease (POST-TEXT) staging was commonly used for assessing the tumor extension after neoadjuvant chemotherapy and evaluating tumor resectability[7]. It was a great challenge in the treatment of POST-TEXT III and IV hepatoblastoma and primary liver transplantation was recommended as surgical option for these patients because of the excellent outcomes[8, 9]. In recent years, a few studies results had showed that non-transplant hepatic resections can achieve similar outcomes with liver transplantation in some selected POST-TEXT III and IV patients[10-13].
The purpose of this study is to evaluate the results of extended hepatic resection in POST-TEXT III and IV hepatoblastoma patients at a Chinese National Children’s Medical Center with long-term follow-up.