Clinical data
The medical records of POST-TEXT III and IV hepatoblastoma patients admitted to Children’s Hospital of Fudan University from January 2009 to June 2019 were analyzed retrospectively. The study was approved by the institution scientific and ethics committee of our hospital. Informed consent was obtained from all legal guardians of the children who agreed to participate in this study. The staging of hepatoblastoma is based on the pretreatment extent of disease (PRETEXT) system. Tumor extensions before and after neoadjuvant chemotherapy were referred to as PRETEXT and POST-TEXT, respectively. Variables studied included age at diagnosis, gender, neoadjuvant and adjuvant chemotherapy regimens, a-fetoprotein (AFP) levels, type of operation, operative time, amount of blood loss, histology, and clinical outcomes.