Conclusion

In conclusion, this literature review demonstrates that oral NMP and NMP-SR are effective therapeutic options for managing women requiring luteal phase support during ART treatment, for preventing miscarriage; for preventing preterm birth, and for managing high-risk pregnancy. Both conventional oral NMP and NMP-SR have the advantage of being natural progesterone. NMP-SR provides additional benefits in terms of once-daily dosing, which can facilitate patient compliance, and an improved tolerability profile. Oral NMP-SR represents a valuable option in the therapeutic armamentarium for treating obstetric conditions associated with insufficient progesterone exposure.