Search method to identify
studies
Searches were performed in PubMed and Cochrane Register from inception
of each database to 17 September 2019 using the words ‘micronized
progesterone’, ‘micronised progesterone’ and ‘oral’. All records (n =
295 for ‘micronized progesterone’ and ‘oral’; n = 29 for ‘micronised
progesterone’ and ‘oral’) were examined to identify relevant articles
for inclusion. Systematic reviews identified in searches were reviewed
for additional studies. No restrictions were applied for language or
geographical location. The searches identified 17 studies of oral NMP
and three studies of NMP-SR in the obstetric indications of interest.
Depending on study methodology (e.g. randomised controlled trial
[RCT], observational study), oral NMP or NMP-SR were investigated
alone or were compared with no treatment, placebo, other progesterone
formulations (vaginal, IM) or oral dydrogesterone. The results are
tabulated and are reported narratively per obstetric indication.