2. METHODS AND MATERIALS
2.1. Histidine Chemical and Post-translational Modifications There are eight chemical and Post-Translational Modifications (PTM)
(functions) annotated in this work (Figure 1). These His modifications,
namely, acetylation, ribosylation, glycosylation, hydroxylation,
methylation, oxidation, phosphorylation, and protein splicing, are
discussed below.