Conclusion:
The increased incidence of ischemic stroke was frequently encountered among patients with ARDS and a significant inflammatory response. We hypothesized that the underlying pathophysiology could be related to the considerable inflammation, deranged coagulation, and viral cell invasion through endothelial ACE2 receptors; this finding warranted the suggestion of a full dose of anticoagulation for the hospitalized patient with moderate to severe COVID-19 pneumonia. Such observations need further studies to define the exact mechanism by which SARS-COV-2 induces ischemic stroke.