Exercise provocation tests
There were 20 CM allergy patients who developed allergic symptoms at the
first EPT (Figure 1). One CM-EPT-negative patient experienced a
convincing event of EIARD at home. Therefore, 21 patients (49%) were
diagnosed as EIARD-positive, and 22 patients were EIARD-negative for CM.
Table S1 shows the characteristics and the results of EPTs of the 21 CM
EIARD-positive patients. There were eight (38%) patients who were
administered antihistamines and eight (38%) patients who were
administered β2 stimulants, of whom one received both antihistamines and
β2 stimulants at the first EPT. Two patients received an intramuscular
injection of adrenaline for anaphylactic shock (cases 17 and 19). Of
these 21 CM EIARD-positive patients, seven (33%) underwent a second
EPT, of whom four tested negative (Figure 1). The second EPT was
performed within a median of 1.5 (range: 0.9–3.4) years after the first
EPT.
Among the 31 patients with a wheat allergy, 14 patients were
EPT-positive (Figure 2). One wheat-EPT-negative patient experienced
EIARD at home. Thus, 15 patients (48%) were diagnosed to be
EIARD-positive and 16 patients were EIARD-negative for wheat. Table S2
shows the characteristics of the 15 wheat EIARD-positive patients. There
were seven (47%) patients who were administered antihistamines and six
(40%) patients who were administered β2 stimulants, of whom five
received both antihistamines and β2 stimulants at the first EPT. None of
the patients received adrenaline. In total, six (40%) patients who
tested positive during the first EPT underwent a second EPT after a
median of 2.1 (range: 0.4–5.9) years. Of these, four tested negative
(Figure 2).