Legends for figures:
Title :TFEB-mediated autophagy in ovarian endometriosis
AMPK:Serine/threonine kinase AMP-activated protein kinase
SIRT1: silent information regulator 1
PGC-1a:peroxisome proliferator-activated receptor gamma, coactivator 1
alpha
Description: In ovarian endometriosis, free iron stimulates ROS
production and activates TFEB in ways that independent of mTOR. Firstly,
ROS can directly oxidize TFEB. Secondly, ROS can promote the release of
lysosomal Ca2+ through MCOLN1, Ca2+ activate calcineurin which can
dephosphorylate TFEB. In addition, ROS can regulate sirt-1 through AMPK,
which can activate TFEB directly or through PGC-1. The activated or
dephosphorylated TFEB can enters the nucleu and promote the
transcription and expression of lysosome and autophagy related genes,
form autophagic lysosome, phagocytize metabolic wastes and abnormal
organelles, release amino acids and recycled by cells, which can lead to
cell proliferation and endometriosis infiltration.