Conclusion and Perspectives
In conclusion, autophagy plays an indispensable role in the occurrence
and development of endometriosis. TFEB, as a key regulator of autophagy,
its upstream and downstream signal molecules have abnormal expression in
endometriosis. Moreover, apoptosis can be inhibited by TFEB mediated
autophagy induction. Therefore, TFEB may be an important regulatory
point of abnormal autophagy levels in endometriosis. At present, the
treatment of endometriosis is still limited to hormone and surgery.
However, hormone therapy is easy to relapse, and there are many side
effects. Moreover, not all women with endometriosis have a response to
hormonal therapy, and surgery is an invasive treatment. Therefore, it is
necessary to find a new treatment for endometriosis, Autophagy is a good
perspective for us to understand endometriosis, TFEB may also become a
potential target for the treatment of endometriosis.