Hemolytic anemia has been associated with SARS-CoV-2 infection in adult
and pediatric patients, we report a case series of preterm newborns with
hemolytic anemia whose mothers had a history of SARS-CoV-2 infection. In
two of the cases maternal infection occurred early in pregnancy and the
newborns had a reactive SARS-CoV-2 antibody test. Hemolysis and
coagulopathy improved with the use of washed blood products and
prothrombin complex concentrate. Our cases highlight the need for
increased awareness of a possible association between hemolysis and
exposure to SARS-CoV-2 infection during intrauterine life.