Laboratory Parameters
We collected hematologic and coagulation laboratory values on each
patient in the preoperative, intraoperative, and postoperative setting.
Laboratory values were collected up until the time of discharge. The
minimum hematocrit, platelet count, and fibrinogen values were recorded,
while the maximum PT and PTT were recorded. There were no differences in
the minimum or maximum values of the collected laboratory parameters in
the preoperative, intraoperative, immediate postoperative, or
postoperative time periods (Table 5). Postoperative laboratory
parameters are depicted in spaghetti plots in Supplementary Figure 1.
Hematocrit dropped as expected in the intraoperative period and many
patients experienced a second drop in the postoperative period, but
nadir and recovery were highly variable. No patients developed
significant thrombocytopenia during the perioperative period. There was
a trend toward a small peak in PT around 24-36 hours postoperative, but
this was also variable with several outliers. PTT tended to rise with
time in the postoperative period, but this was only collected on a few
patients (n=11). Hypofibrinogenemia was not seen and fibrinogen activity
tended to increase postoperatively.