Author Contributions
LWB& SCM conceived and designed the experiments, supervised the experiments and revised the manuscript. SCX performed the experiments, analysed the data and drafted the manuscript. YSF and WJW took part in the animal experiments and analysis of optical properties. DLY and LJJ participated in Flow Cytometerand western blot analysis. FQ and ZY contributed to collecting humantissues. All authors have read and approved the final manuscript.