Immunometabolism has emerged as one of the exciting areas in the field of translational research. More recently, the role of cellular metabolism in the development and function of immune cells in healthy and diseased individuals has been described in diseases such as cancer, autoimmunity, and organ transplantation. Metabolic reprogramming of distinct T cell subsets is the center for appropriate T cell differentiation and function [1-3]. In this line, T cells use many different metabolic pathways to generate ATP for their survival and boost numerous molecular biosynthetic precursors production for their proper prolif­eration and differentiation [4]. These metabolic pathways entail diverse end products, but they are interconnected on shared fuel ground. For example, fatty acid synthesis pathway is dependent on the availability of intermediate products from the glycolysis and tricarboxylic acid (TCA) cycle metabolism. Thus, metabolic regulome of immune cells is a key factor in the control of immune responses.