Metabolic Pathway | Drug | Target | Effect on Tregs | Diseases | Model animal | Reference |
Glucose metabolism | 2-DG Dichloroacetate | Glycolysis PDHK | Induce Treg differentiation Induce Treg generation | Skin and heart transplantation EAE | Mouse Mouse | [101] [61] |
Lipid metabolism | Soraphen A | acetyl-CoA carboxylase inhibitors | Induce pTreg differentiation | EAE | Mouse | [108] |
Glutamine metabolism | DON | Glutamine uptake | Induce Treg generation | Skin and heart transplantation | Mouse | [103] |
Metabolic regulators | Rapamycin Metformin | mTORC1 AMPK | Enhance Treg cell expansion and stability Induce Treg differentiation | Graft Rejection Skin and heart transplantation | Human Mouse | [113] [106] |
Epigenetic inhibtor | JQ1 | BET bromodomain inhibitor | Enhanced expression of LKB1 and provide stability to Treg | Heart transplantation | Mouse | [112] |