Fig.1 Factors that influences metabolic phenotype of inflammatory and anti-inflammatory immune cells towards anti-inflammatory phenotype: The various immune cell subtype reliance on distinct metabolic pathways to promote their survival, lineage subtype and function in the presence of several factors. mTOR-HIF1-α signaling axis promote inflammatory macrophages (M1) and effector T cells (Th1,Th2,Th17) proliferation and function through utilizing glycolysis, fatty acid synthesis and amino acid metabolism as a main energy source. Contray to this, Tregs, Tmem and M2 macrophages, which show a more tolerant phenotype, use the TCA cycle and fatty acid oxidation for their energy source under the influence of LKB1 signaling. Figure created with Biorender.com