REFERENCES
1. Ogwang MD, Bhatia K, Biggar RJ, Mbulaiteye SM. Incidence and geographic distribution of endemic Burkitt lymphoma in northern Uganda revisited. Int J cancer . 2008;123(11):2658-2663. doi:10.1002/ijc.23800
2. Kalisz K, Alessandrino F, Beck R, et al. An update on Burkitt lymphoma: a review of pathogenesis and multimodality imaging assessment of disease presentation, treatment response, and recurrence.Insights Imaging . 2019;10(1):56. doi:10.1186/s13244-019-0733-7
3. Mbulaiteye SM, Anderson WF, Ferlay J, et al. Pediatric, elderly, and emerging adult-onset peaks in Burkitt’s lymphoma incidence diagnosed in four continents, excluding Africa. Am J Hematol . 2012;87(6):573-578. doi:10.1002/ajh.23187
4. Morton LM, Wang SS, Devesa SS, Hartge P, Weisenburger DD, Linet MS. Lymphoma incidence patterns by WHO subtype in the United States, 1992-2001. Blood . 2006;107(1):265-276. doi:10.1182/blood-2005-06-2508
5. Derinkuyu BE, Boyunağa Ö, Öztunalı Ç, et al. Imaging features of Burkitt lymphoma in pediatric patients. Diagn Interv Radiol . 2016;22(1):95-100. doi:10.5152/dir.2015.15211
6. Egan G, Goldman S, Alexander S. Mature B-NHL in children, adolescents and young adults: current therapeutic approach and emerging treatment strategies. Br J Haematol . 2019;185(6):1071-1085. doi:10.1111/bjh.15734
7. Silva TDB, Ferreira CBT, Leite GB, de Menezes Pontes JR, Antunes HS. Oral manifestations of lymphoma: a systematic review.Ecancermedicalscience . 2016;10:665. doi:10.3332/ecancer.2016.665
8. Balasubramaniam R, Goradia A, Turner LN, et al. Burkitt lymphoma of the oral cavity: an atypical presentation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod . 2009;107(2):240-245. doi:10.1016/j.tripleo.2008.09.008
9. Mbulaiteye SM, Biggar RJ, Bhatia K, Linet MS, Devesa SS. Sporadic childhood Burkitt lymphoma incidence in the United States during 1992-2005. Pediatr Blood Cancer . 2009;53(3):366-370. doi:10.1002/pbc.22047
10. White SC, Pharoah MJ. Oral Radiology: Principles and Interpretation . Fifth edit. Mosby; 2004.
11. Khanna G, Sato Y, Smith RJH, Bauman NM, Nerad J. Causes of facial swelling in pediatric patients: correlation of clinical and radiologic findings. Radiographics . 2006;26(1):157-171. doi:10.1148/rg.261055050
12. Anil Govindrao Ghom. Basic Oral Radiology . First edit. Jaypee brothers medical publishers Ltd; 2014.
13. Storck K, Brandstetter M, Keller U, Knopf A. Clinical presentation and characteristics of lymphoma in the head and neck region. Head Face Med . 2019;15(1):1. doi:10.1186/s13005-018-0186-0
14. Minard-Colin V, Aupérin A, Pillon M, et al. Rituximab for high-risk, mature B-cell non-Hodgkin’s lymphoma in children. N Engl J Med . 2020;382(23):2207-2219. doi:10.1056/NEJMoa1915315
15. Murphy SB. Classification, staging and end results of treatment of childhood non-Hodgkin’s lymphomas: dissimilarities from lymphomas in adults. Semin Oncol . 1980;7(3):332-339.
16. Boon LC, Nik-Hussien NN. Burkitt’s lymphoma in the mandible–a case report. Br J Oral Maxillofac Surg . 1987;25(5):410-414. doi:10.1016/0266-4356(87)90092-1
17. Rodrigues-Fernandes CI, Pérez-de-Oliveira ME, Aristizabal Arboleda LP, et al. Clinicopathological analysis of oral Burkitt’s lymphoma in pediatric patients: A systematic review. Int J Pediatr Otorhinolaryngol . 2020;134:110033.
18. Palmer RM, Lumsden AG. Development of periodontal ligament and alveolar bone in homografted recombinations of enamel organs and papillary, pulpal and follicular mesenchyme in the mouse. Arch Oral Biol . 1987;32(4):281-289. doi:10.1016/0003-9969(87)90022-7
19. Curtis AB. Childhood leukemias: osseous changes in jaws on panoramic dental radiographs. J Am Dent Assoc . 1971;83(4):844-847. doi:10.14219/jada.archive.1971.0405
20. Hanazawa T, Kimura Y, Sakamaki H, Yamaguchi A, Nagumo M, Okano T. Burkitt’s lymphoma involving the mandible: report of a case and review of Japanese cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod . 1998;85(2):216-220. doi:10.1016/s1079-2104(98)90429-2
21. Wood RE, Nortjé CJ, Hesseling P, Mouton S. Involvement of the maxillofacial region in African Burkitt’s lymphoma in the Cape Province and Namibia. Dentomaxillofac Radiol . 1988;17(1):57-60. doi:10.1259/dmfr.1988.0007
22. Dunfee BL, Sakai O, Pistey R, Gohel A. Radiologic and pathologic characteristics of benign and malignant lesions of the mandible.Radiogr a Rev Publ Radiol Soc North Am Inc . 2006;26(6):1751-1768. doi:10.1148/rg.266055189
23. Satheesan E, Tamgadge S, Tamgadge A, Bhalerao S, Periera T. Histopathological and Radiographic Analysis of Dental Follicle of Impacted Teeth Using Modified Gallego’s Stain. J Clin Diagn Res . 2016;10(5):ZC106-11. doi:10.7860/JCDR/2016/16707.7838
24. El-Naggar AK, Chan JK, Grandis JR, Takata T, Slootweg PJ. WHO Classification of Head and Neck Tumours . 4th editio. International Agency for Research on Cancer; 2017.
25. Sandlund JT, Pui C-H, Zhou Y, et al. Effective treatment of advanced-stage childhood lymphoblastic lymphoma without prophylactic cranial irradiation: results of St Jude NHL13 study. Leukemia . 2009;23(6):1127-1130. doi:10.1038/leu.2008.400
26. Gerrard M, Cairo MS, Weston C, et al. Excellent survival following two courses of COPAD chemotherapy in children and adolescents with resected localized B-cell non-Hodgkin’s lymphoma: results of the FAB/LMB 96 international study. Br J Haematol . 2008;141(6):840-847. doi:10.1111/j.1365-2141.2008.07144.x
27. Avril L, Lombardi T, Ailianou A, et al. Radiolucent lesions of the mandible: a pattern-based approach to diagnosis. Insights Imaging . 2014;5(1):85-101. doi:10.1007/s13244-013-0298-9
Figure 1. Intra-oral image of friction lesion at the level of the left cheek (A ). Oral lesion after biopsy and chemotherapy (B ).
Figure 2. Panoramic radiograph with an osteolytic lesion at the left corner of the jaw. Mark the absence of a cortical border around the follicular sac. (compare with the contralateral side)
Figure 3 . Coronal PET-CT image showing various abdominal metastases, mark the femoral hyperintensity (A ). Axial MRI image showing the lesion of the left jaw (B ). Axial CT image of a mass in the left masseter muscle region, fixed on the ascending mandibular ramus with osteolysis of the bony tissue (C ).
Figure 4 . Histopathology of an incisional biopsy of the mucosa of the jaw (A ). H&E stain shows the lesion is composed of a diffuse proliferation of medium-sized, monomorphic blastoid cells with round vesicular to hyperchromatic nuclei. The nuclei contained small nucleoli and numerous mitotic figures were present. Between the cells there are tingible body macrophages giving rise to a starry sky appearance. The cells express CD20 (B ), CD10 (C ), but no BCL2 (D ). The proliferation index is very high (E ), and there is nuclear expression of MYC (F ) in the majority of cells, due to a MYC-rearrangement, proven by FISH. All images are taken at 400X magnification, except A , taken at 200X.