Blood transfusion is an important method in clinical treatment. The lack
of blood donors and risk of contamination caused by blood transfusion
has become a worldwide problem. Technology of mimicking platelets is
imperative, with the greatest potential to significantly improve
hemostatic action and break barriers of time and space. So that, many
scientists have devoted to the research of artificial human
hematopoietic cells. Imitations of the natural form and function of
platelets are still limited by many reasons until now. In this review,
we mainly focus on the constructive progress of platelet analogues based
on its innate hemostatic abilities in the past 20 years. It hopes to
convey a more comprehensive understanding of design elements, advanced
technologies and major challenges in this domain.