Objectives. The aim of this study was to investigate the epidemiology of RSV bronchiolitis and the influence of meteorological and air pollutant factors on the isolation of RSV in infants admitted for viral bronchiolitis during three consecutive years, before and during the COVID-19 pandemic, in Bogota, Colombia, a middle-income country (MIC) with a tropical climate. Methods. An analytical cross-sectional study was conducted before and during the COVID-19 pandemic, including patients with a diagnosis of viral bronchiolitis admitted to all the hospitals of the city between January 2019 and November 2021. Predictor variables included meteorological and air pollutant parameters. We adjusted multivariable analysis to identify factors independently associated with isolation of RSV as the causative agent of viral bronchiolitis. Results. A total of 12,765 patients were included in the study. After controlling for potential confounders, it was found that age (OR 0.87; CI 95% 0.77–0.98; p=0.029), COVID-19 pandemic (OR 0.74; CI 95% 0.64–0.86; p<0.001), temperature (OR 1.85; CI 95% 1.47–2.33; p<0.001), and interaction terms between SES and NO2 (OR 1.04; CI 95% 1.01–1.07; p=0.002), and between rainfall and NO2 (OR 0.99; CI 95% 0.998–0.999; p=0.010) independently predicted the isolation of RSV as the causative agent of viral bronchiolitis in our sample of patients. Conclusions. The identified predictors for isolation of RSV as the causative agent of viral bronchiolitis provide additional scientific evidence that may be useful in the development of specific interventions aimed at ameliorating or preventing the impact of RSV in Bogota and probably other similar LMICs in high-risk infants.

Objectives. We aimed to validate a Spanish version of the Sleep-Related Breathing Disorder scale of the Pediatric Sleep Questionnaire (SRBD-PSQ) in children living in a high-altitude Colombian city. Methods. In a prospective cohort validation study, patients aged between 2 and 18 years who attended the Ear, Nose, and Throat pediatric department of our institution for symptoms related to sleep-related breathing disorders had a baseline visit at enrollment, a second visit the day scheduled for the surgical intervention, and a follow-up visit at least three months after the surgical intervention. In these three visits, we gathered the necessary data for assessing the criterion validity, construct validity, test–retest reliability, internal consistency, and sensitivity to change of the Spanish version of the SRBD-PSQ. Results. In total, 121 patients were included in the analyses. The exploratory factor analysis (generalized least squares method, varimax rotation) yielded a four-factor structure, explaining 65.93% of the cumulative variance. The intraclass correlation coefficient (ICC) of the measurements was 0.887 (95% CI: 0.809–0.934), and the Lin concordance correlation coefficient was 0.882 (95% CI, 0.821-0.943). SRBD-PSQ scores at baseline were significantly higher than those obtained after adeno-tonsillectomy surgery (median [IQR] 11.0 [9.0- 14.0] vs. 4.00 [1.50- 7.0]; p<0.0001). Cronbach’s α was 0.7055 for the questionnaire as a whole. Conclusions. The Spanish version of the SRBD-PSQ has acceptable construct validity, excellent test-retest reliability and sensitivity to change, and adequate internal consistency-reliability when used in pediatric patients living at high altitude with symptoms related to sleep-related breathing disorders.