WHAT IS KNOWN?
- PMN-MDSCs are involved in the progression of NSCLC by promoting tumor
immune escape and metastasis.
- Initially, PMN-MDSCs shared similar morphology and phenotype with
mature neutrophils, and the suppressive activity was the most reliable
approach to identify PMN-MDSCs.
- LOX-1 is a newly confirmed maker for identifying PMN-MDSCs in human.