Non-PCOS Non-PCOS Non-PCOS PCOS PCOS PCOS
Variables n PY IR n PY IR cHR (95% CI) aHRꝉ (95% CI)
Age, year
20-30 108 98651 1.09 27 24958 1.08 0.99 (0.65,1.51) 0.96 (0.63,1.47)
31-40 52 52931 0.98 31 13210 2.35 2.38 (1.53,3.72)*** 2.31 (1.48,3.61)***
41-50 10 8673 1.15 1 2135 0.47 0.40 (0.05,3.16) 0.38 (0.05,2.96)
Comorbidities
asthma
No 164 154157 1.06 55 38383 1.43 1.35 (0.99,1.83) 1.31 (0.97,1.79)
Yes 6 6098 0.98 4 1921 2.08 2.16 (0.61,7.66) 1.99 (0.55,7.15)
anxiety
No 169 159918 1.06 59 40167 1.47 1.39 (1.03,1.87)* 1.35 (1.00 ,1.82)*
Yes 1 336 2.97 0 137 0.00 0.00 (0,Inf) 0.00 (0,Inf)
CAD
No 167 159163 1.05 57 39952 1.43 1.36 (1.01,1.84)* 1.33 (0.98,1.80)
Yes 3 1092 2.75 2 352 5.68 2.09 (0.35,12.5) 1.74 (0.29,10.6)
cancer
No 170 159791 1.06 59 40211 1.47 1.38 (1.03,1.85)* 1.34 (1.00,1.81)
Yes 0 463 0.00 0 93 0.00
COPD
No 149 144616 1.03 52 35488 1.47 1.42 (1.04,1.95)* 1.38 (1.00,1.89)*
Yes 21 15638 1.34 7 4816 1.45 1.09 (0.46,2.56) 1.09 (0.46,2.56)
CHF
No 170 160029 1.06 59 40213 1.47 1.38 (1.03,1.86)* 1.34 (1.00,1.81)
Yes 0 226 0.00 0 91 0.00
CLD
No 162 151992 1.07 52 36957 1.41 1.32 (0.97,1.80) 1.28 (0.94,1.76)
Yes 8 8262 0.97 7 3347 2.09 2.26 (0.82,6.23) 2.28 (0.82,6.31)
diabetes
No 166 158371 1.05 55 39200 1.40 1.34 (0.99,1.82) 1.32 (0.98,1.80)
Yes 4 1883 2.12 4 1104 3.62 1.71 (0.43,6.86) 1.74 (0.43,7.02)
depression
No 160 154306 1.04 54 38347 1.41 1.36 (1.00,1.85) 1.32 (0.97,1.80)
Yes 10 5949 1.68 5 1957 2.55 1.48 (0.51,4.34) 1.52 (0.52,4.45)
hypertension
No 167 157821 1.06 58 39239 1.48 1.40 (1.04,1.88)* 1.36 (1.01,1.84)*
Yes 3 2434 1.23 1 1065 0.94 0.74 (0.08,7.12) 0.69 (0.07,6.95)
hyperlipidemia
No 169 156266 1.08 53 38189 1.39 1.28 (0.94,1.75) 1.25 (0.92,1.71)
Yes 1 3989 0.25 6 2115 2.84 11.4 (1.37,94.5)* 10.2 (1.21,85.1)*
stroke
No 169 159256 1.06 58 39966 1.45 1.37 (1.01,1.84)* 1.34 (0.99,1.80)
Yes 1 998 1.00 1 338 2.96 2.81 (0.18,45.0) 2.83 (0,Inf)
sleep apnea
No 170 160081 1.06 59 40215 1.47 1.38 (1.03,1.86)* 1.34 (1.00,1.81)
Yes 0 173 0.00 0 89 0.00
*: p-value<0.05; **: p-value<0.01; ***: p-value<0.001; PY: person-years; IR: incidence rate (per 1000 person-years); cHR: crude hazard ratio; aHR: adjusted hazard ratio; CAD: coronary artery disease; COPD: chronic obstructive pulmonary disease; CHF: congestive heart failure; CLD: chronic liver diseases; ꝉ: adjusted for age, CAD, diabetes and depression. *: p-value<0.05; **: p-value<0.01; ***: p-value<0.001; PY: person-years; IR: incidence rate (per 1000 person-years); cHR: crude hazard ratio; aHR: adjusted hazard ratio; CAD: coronary artery disease; COPD: chronic obstructive pulmonary disease; CHF: congestive heart failure; CLD: chronic liver diseases; ꝉ: adjusted for age, CAD, diabetes and depression. *: p-value<0.05; **: p-value<0.01; ***: p-value<0.001; PY: person-years; IR: incidence rate (per 1000 person-years); cHR: crude hazard ratio; aHR: adjusted hazard ratio; CAD: coronary artery disease; COPD: chronic obstructive pulmonary disease; CHF: congestive heart failure; CLD: chronic liver diseases; ꝉ: adjusted for age, CAD, diabetes and depression. *: p-value<0.05; **: p-value<0.01; ***: p-value<0.001; PY: person-years; IR: incidence rate (per 1000 person-years); cHR: crude hazard ratio; aHR: adjusted hazard ratio; CAD: coronary artery disease; COPD: chronic obstructive pulmonary disease; CHF: congestive heart failure; CLD: chronic liver diseases; ꝉ: adjusted for age, CAD, diabetes and depression. *: p-value<0.05; **: p-value<0.01; ***: p-value<0.001; PY: person-years; IR: incidence rate (per 1000 person-years); cHR: crude hazard ratio; aHR: adjusted hazard ratio; CAD: coronary artery disease; COPD: chronic obstructive pulmonary disease; CHF: congestive heart failure; CLD: chronic liver diseases; ꝉ: adjusted for age, CAD, diabetes and depression. *: p-value<0.05; **: p-value<0.01; ***: p-value<0.001; PY: person-years; IR: incidence rate (per 1000 person-years); cHR: crude hazard ratio; aHR: adjusted hazard ratio; CAD: coronary artery disease; COPD: chronic obstructive pulmonary disease; CHF: congestive heart failure; CLD: chronic liver diseases; ꝉ: adjusted for age, CAD, diabetes and depression. *: p-value<0.05; **: p-value<0.01; ***: p-value<0.001; PY: person-years; IR: incidence rate (per 1000 person-years); cHR: crude hazard ratio; aHR: adjusted hazard ratio; CAD: coronary artery disease; COPD: chronic obstructive pulmonary disease; CHF: congestive heart failure; CLD: chronic liver diseases; ꝉ: adjusted for age, CAD, diabetes and depression. *: p-value<0.05; **: p-value<0.01; ***: p-value<0.001; PY: person-years; IR: incidence rate (per 1000 person-years); cHR: crude hazard ratio; aHR: adjusted hazard ratio; CAD: coronary artery disease; COPD: chronic obstructive pulmonary disease; CHF: congestive heart failure; CLD: chronic liver diseases; ꝉ: adjusted for age, CAD, diabetes and depression. *: p-value<0.05; **: p-value<0.01; ***: p-value<0.001; PY: person-years; IR: incidence rate (per 1000 person-years); cHR: crude hazard ratio; aHR: adjusted hazard ratio; CAD: coronary artery disease; COPD: chronic obstructive pulmonary disease; CHF: congestive heart failure; CLD: chronic liver diseases; ꝉ: adjusted for age, CAD, diabetes and depression. *: p-value<0.05; **: p-value<0.01; ***: p-value<0.001; PY: person-years; IR: incidence rate (per 1000 person-years); cHR: crude hazard ratio; aHR: adjusted hazard ratio; CAD: coronary artery disease; COPD: chronic obstructive pulmonary disease; CHF: congestive heart failure; CLD: chronic liver diseases; ꝉ: adjusted for age, CAD, diabetes and depression. *: p-value<0.05; **: p-value<0.01; ***: p-value<0.001; PY: person-years; IR: incidence rate (per 1000 person-years); cHR: crude hazard ratio; aHR: adjusted hazard ratio; CAD: coronary artery disease; COPD: chronic obstructive pulmonary disease; CHF: congestive heart failure; CLD: chronic liver diseases; ꝉ: adjusted for age, CAD, diabetes and depression. *: p-value<0.05; **: p-value<0.01; ***: p-value<0.001; PY: person-years; IR: incidence rate (per 1000 person-years); cHR: crude hazard ratio; aHR: adjusted hazard ratio; CAD: coronary artery disease; COPD: chronic obstructive pulmonary disease; CHF: congestive heart failure; CLD: chronic liver diseases; ꝉ: adjusted for age, CAD, diabetes and depression.