Research Implications
One theoretical mechanism is hyperestrogenic state in PCOS. Hyperestrogenism increased autoimmune diseases by having a proliferative action on B‑lymphocytes, T‑cell and macrophages.(18, 19) The positive result of our study serves as a retrospective population-based evidence to sustain previous observations of the interplay between the two clinical conditions. The relationship between PCOS and Graves’ diseases might be more than a mere coincident finding in coexistence.