Research Implications
One theoretical mechanism is hyperestrogenic state in PCOS.
Hyperestrogenism increased autoimmune diseases by having a proliferative
action on B‑lymphocytes, T‑cell and macrophages.(18, 19) The positive
result of our study serves as a retrospective population-based evidence
to sustain previous observations of the interplay between the two
clinical conditions. The relationship between PCOS and Graves’ diseases
might be more than a mere coincident finding in coexistence.