The CYP1A1 A2455G polymorphism and CRC risk
Tables 3 shows the pooled results on the association between the CYP1A1
A2455G polymorphism and CRC risk. A significantly increased CRC risk was
yielded in overall analysis (GG vs. AA: OR = 1.39, 95% CI: 1.03–1.88;
GG vs. (AG + AA): OR = 1.32, 95% CI: 1.10–1.57). Then, Subgroups were
conducted by ethnicity, geographic region, location of CRC, gender, and
smoking. A significantly increased CRC risk was also found in Caucasians
(AG vs. AA: OR = 1.26, 95% CI: 1.10–1.46; GG vs. AA: OR = 1.71, 95%
CI: 1.00–2.93; (AG + GG) vs. AA: OR = 1.27, 95% CI: 1.04–1.54; G vs.
A: OR = 1.27, 95% CI: 1.12–1.43), Europe countries populations (AG vs.
AA: OR = 1.43, 95% CI: 1.20–1.70; (AG + GG) vs. AA: OR = 1.45, 95%
CI: 1.23–1.72; G vs. A: OR = 1.43, 95% CI: 1.22–1.66), and males ((AG
+ GG) vs. AA: OR = 1.47, 95% CI: 1.12–1.94). after BFDP correction,
association was still significant in Europe countries populations (AG
vs. AA: BFDP = 0.680; (AG + GG) vs. AA: BFDP = 0.475; G vs. A: BFDP =
0.126).