FIGURE LEGENDS
Figure 1 . Schematic diagram of the predominant mRNA covalent modifications. Reactions for methylation at nucleosides, pseudouridylation and adenosine-to-inosine edition are illustrated. The known writers (W), erasers (E) and readers (R) for each RNA modification are listed together with the modification. Ψ, pseudouridine; I, Adenosine-to-Inosine edition; m1A, N1-methyladenosine; m5C, 5‑methyl cytidine; m6A, N6-methyladenosine.
Figure 2. Challenges and difficulties for drug discovery targeting RNA-modifiers.