Definitions
Nephrotoxicity was evaluated according to the RIFLE (Risk, Injury,
Failure, Loss, End-stage kidney disease) criteria based on serum
creatinine concentrations. According to this system, risk (R) is defined
as a 1.5-fold increase in serum creatinine concentration, injury (I) as
a 2-fold increase in serum creatinine concentration, and failure (F) as
a 3-fold increase in serum creatinine or concentration ≥4 mg/dL; loss
(L) is defined as persistent acute renal failure >4 weeks
and end-stage renal disease (E) is defined as persistent failure
>3 months (10). Infection was diagnosed according to the
criteria defined by the Centers for Disease Control and Prevention (11).
Urea and creatinine concentrations on the first day of COL therapy were
accepted as initial values. In patients with nephrotoxicity, the dose of
COL was adjusted according to creatinine clearance. Urea and creatinine
concentrations on the day of discontinuation of COL treatment were
evaluated as end-of-treatment values.