Statistical analysis
SPSS Statistics version 18.0 (SPSS Inc. 1989, 2010) software was used to analyze the data. The Shapiro Wilk test was used to assess the normality of data distribution. The homogeneity of variance was evaluated using Levene test. Groups were compared using chi-square or Fisher’s exact test for categorical variables, and the independent-samples t-test and Mann–Whitney U test were used for continuous variables. Quantitative variables were shown as mean ± standard deviation (SD) or median (minimum–maximum), and categorical variables as number (n) and percentage (%). Potential factors for COL nephrotoxicity identified by univariate analyses were analyzed using a multiple logistic regression model. The variables were examined using odds ratio (OD) with 95% confidence intervals, and p values less than 0.05 were accepted as significant.
Ethics approval: Ethics committee approval was received from Niğde Ömer Halisdemir University Ethics Committee (Reference number: 2018/13-21).