Statistical analysis
SPSS Statistics version 18.0 (SPSS Inc. 1989, 2010) software was used to
analyze the data. The Shapiro Wilk test was used to assess the normality
of data distribution. The homogeneity of variance was evaluated using
Levene test. Groups were compared using chi-square or Fisher’s exact
test for categorical variables, and the independent-samples t-test and
Mann–Whitney U test were used for continuous variables. Quantitative
variables were shown as mean ± standard deviation (SD) or median
(minimum–maximum), and categorical variables as number (n) and
percentage (%). Potential factors for COL nephrotoxicity identified by
univariate analyses were analyzed using a multiple logistic regression
model. The variables were examined using odds ratio (OD) with 95%
confidence intervals, and p values less than 0.05 were accepted as
significant.
Ethics approval: Ethics committee approval was received from
Niğde Ömer Halisdemir University Ethics Committee (Reference number:
2018/13-21).