18-64 years n=18 (16.2%) ≥ 65 years n=88 (83%)
p value
APACHE II (mean±SD) 22.17±7.61 25.78±6.542 0.04
Duration of hospitalization before COL therapy, median (min-max) 17 (5-43) 18 (3-101) 0.930
Initial serum urea (mg/dL) median (min-max) 36 (20-99) 52 (16-125) 0.081
Initial serum creatinine (mg/dL) (mean±SD) 0.74±0.191 0.78±0.204 0.424
End-treatment serum urea (mg/dL) median (min-max) 85.5 (36-266) 117.5 (43-295) 0.089
End-treatment serum creatinine (mg/dL) median (min-max) 2.34 (0.73-5.68) 2.56 (1-8) 0.970
Total colistin day, median (min-max) 14 (5-22) 10 (4-23) 0.123
Colistin toxicity day, median (min-max) 7.5 (2-19) 5 (2-18) 0.236
Underlying diseases, n (%) Chronic obstructive pulmonary disease Diabetes mellitus Coronary artery disease Cardiac failure Immunosupression Solid organ malignancy 8 (44.4) 7 (38.9) 3 (16.7) 1 (5.6) 5 (27.8) 0 (0.0) 53 (60.2) 23 (26.1) 27 (30.7) 23 (26.1) 2 (2.3) 3 (3.4) 0.217 0.274 0.229 0.067 0.001 1.00
Vasopressor agent use, n (%) 5 (27.8) 55 (62.5) 0.009
Concomitant nephrotoxic agent use, n (%) 13 (72.2) 63 (71.6) 0.957
Need for hemodialysis, n (%) 1 (5.6) 4 (4.5) 1.00
14-day mortality, n (%) 4 (22.2) 46 (52.3) 0.02
28-day mortality, n (%) 6 (40) 31 (73.8) 0.019
Overall mortality, n (%) 14 (77.8) 84 (95.5) 0.027