Statistical analysis
PFS and overall survival (OS) were estimated by the Kaplan-Meier method with Rothman’s 95% confidence interval (CI). Meanwhile, median follow-up was estimated by the reverse Kaplan-Meier method. Hazard ratios (HR) and 95% CIs of multivariate Cox proportional hazard models were used to explore the effects of MTX intrathecal injection. Nonparametric data were compared by Mann-Whitney U test. The statistical significance level was set at p < 0.05. GraphPad Prism 9.4 was employed for all statistical and image analyses.