Statistical analysis
PFS and overall survival (OS) were estimated by the Kaplan-Meier method
with Rothman’s 95% confidence interval (CI). Meanwhile, median
follow-up was estimated by the reverse Kaplan-Meier method. Hazard
ratios (HR) and 95% CIs of multivariate Cox proportional hazard models
were used to explore the effects of MTX intrathecal injection.
Nonparametric data were compared by Mann-Whitney U test. The statistical
significance level was set at p < 0.05. GraphPad Prism
9.4 was employed for all statistical and image analyses.