Results
The baseline characteristics of patients and controls are given intable 1 . PHPT group’s and control group’s average ages are 56.9 (49-68) and 56.8 (49-66), respectively. There were no significant differences between groups regarding age, gender, hypertension, diabetes mellitus, Hyperlipidemia, and smoking.
Echocardiographic and atrial electromechanical time parameters are shown in table 2. LV systolic and diastolic diameters, left atrial diameter, interventricular septum, posterior wall thickness, and LV ejection fraction were similar in two groups.
There was no difference between PHPT and healthy subjects in cardiovascular function parameters, except for IVRT, which was significantly longer in PHPT patients and indicated abnormal LV relaxation (86.05±10.39 vs 100.15±9.93 p<0.01).
Atrial EMD parameters (PA lateral, PA septum, PA tricuspid) significantly increased in PHPT group compared to control group (76,62±6,78 vs 64,13±8,03, 64,13±4,87 vs 53,97±5,98, 47,09±6,60 vs 43,55±7,38, p<0.01, p<0.01, p<0.01, respectively). Also, inter-atrial and intra-atrial EMD were higher in PHPT group compared to control group (29,52±9,12 vs 20,57±8,63, 17,03±7,78 vs 10,42±6,27, p<0.01, p <0.01, respectively). Left atrial EMD was higher in PHPT group but it did not reach to significance (12,49±7,74 vs 10,15±8,05, p =0.171) (figure 1 ).
Biochemical parameters are shown in table 3 . Serum phosphorus were significantly lower in PHPT compared to control group (median 3.72, interquartile range 3.5 to 4.0 vs median 2.62, interquartile range 2.3 to 2.9, p<0.01). On the other hand, calcium and parathyroid hormone were higher in PHPT group compared to control group (median 10.86, interquartile range 10.5 to 11.2 vs median 9.16, interquartile range 8.7 to 9.5; median 251.8, interquartile range 139.7 to 255.5 vs median 35.6, interquartile range 31.5 to 41.0. p<0.01, p<0.01, respectively). Other blood parameters were similar between the two groups (table 3 ).
In correlation analysis, calcium was well associated with PA lateral (r=0.748, p<0.001) PA septum (r = 0.720, p <0.001), inter-atrial EMD (r = 0.670, p <0.001) and intra-atrial EMD (r = 0.616, p <0.001) (figure 2 ).
There was the same correlation relationship between PTH levels with PA lateral (r=671, p<0.001), PA septum (r=-0.660, p<0,001), inter-atrial EMD (r=0.674, p<0,001) and intra-atrial EMD (r=0.732, p<0.001) (figure 3 ).