Atrial Electromechanical Delay Is Impaired in Patients with
Primary Hyperparathyroidism
Abstract
Aim: Primary hyperparathyroidism (PHPT) is an endocrine disease
that poses a risk for cardiac arrhythmias. Atrial electromechanical
delay (EMD) has been known as an early marker of atrial fibrillation
(AF). This study aimed to evaluate the atrial EMD in PHPT.
Methods: Fifty PHPT patients (45 females, 5 males) aged 30-75
years and 38 controls (35 females, 3 males) aged 31-73 years were
included in the study. Atrial EMD parameters were measured by
using tissue Doppler imaging (TDI). Inter-atrial EMD was calculated as
the difference between PA lateral and PA tricuspid, intra-atrial EMD was
calculated as the difference between PA septum and PA tricuspid, and
left-atrial EMD was calculated as the difference between PA lateral and
PA septum
Results : Atrial EMD parameters (PA lateral, PA septum, PA
tricuspid) significantly increased in PHPT group compared to control
group (p<0.001, for all). Also, inter-atrial and intra-atrial
EMD were higher in PHPT group compared to control group
(p<0.001, for all). In correlation analysis, calcium was well
associated with PA lateral (r=0.748, p<0.001), PA septum (r =
0.720, p <0.001), inter-atrial EMD (r = 0.670, p
<0.001) and intra-atrial EMD (r = 0.616, p <0.001).
There was the same correlation relationship between PTH levels with PA
lateral (r=671, p<0.001), PA septum (r=0.660,
p<0,001), inter-atrial EMD (r=0.674, p<0,001) and
intra-atrial EMD (r=0.732, p<0.001).
Conclusions: Atrial EMD parameters were prolonged in PHPT. The
measurement of atrial EMD parameters might be used to determine the risk
of development of AF in PHPT.
Key words: Primary hyperparathyroidism, atrial fibrillation,
electromechanical delay.