Figure 1. Elevated estimated PA pressure and pulmonary vascular resistance in PEC. Flow characteristics in the RV outflow tract (RVOT) were examined using TTE as described in methods. Data shown are scatter plots of individual measurements overlaid with Mean±95% C.I. of: (A) Estimated mean pulmonary arterial pressure. Reference range is indicated by dashed lines. (B) RVOT Doppler waveform PAAT; inversely correlated with PA pressure and pulmonary vascular resistance). A 100ms cutoff (reference value) is indicated with dashed line. PAAT<100ms detects PAH with sensitivity=0.84 and specificity=0.9 (C) PVR estimated as PVR=(estimated MPAP)/RV CO, (D) RVMPI. estimated MPAP, estimated PVR and RVMPI increased and PAAT decreased in early PEC as compared to early and in late PEC vs late controls. Statistics by ANOVA with Bonferroni’s post hoc analysis, * = P<0.05, ** = P<0.01, ***=P<0.01, **** = P<0.0001. PVR: pulmonary vascular resistance, estimated MPAP: estimated mean pulmonary arterial pressure; RVOT: right ventricular outflow tract; PAAT: pulmonary artery acceleration time; RV: right ventricle; MPI: myocardial performance index; PA: pulmonary artery; PEC: pre-eclampsia