Determination of biochemical indexes
On day 3 and day 6 after the last administration, blood samples were taken from the peripheral blood of the mice and centrifuged to obtain the serum. The alanine transferase (ALT), aspartic acid transferase (AST), creatinine (Cr), and lactate dehydrogenase (LDH) activities in the serum were detected according to the kit (Amyjet Scientific, Wuhan, China) instructions.