CONCLUSION
In this study, we firstly demonstrated that de-escalation therapy played
a novel immunomodulatory effect during sepsis, which was depended on the
NET formation. The early use of NET-promoting antibiotics (maximizing
the capacity of capturing bacteria) in the early stage, followed by
NET-inhibiting antibiotics in the late stage (preventing NET-associated
organ injury), may be a reasonable treatment algorithm for the treatment
of sepsis. Our study may shed lights on immunotherapy treatment in
sepsis that involves the detection of NETs and usher the treatment of
sepsis into the era of precision medicine and individualized therapy.